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Risks of accidental human injection of veterinary antibiotics or vaccines

Posted Nov 04 2009 10:03pm

Accidental human injection of Excenel RTU: ceftiofur hydrochloride in cottonseed oil

Gwynne-Jones,D.; Lyall,P.; Hung,N.A.; Meikle,G.
Clinical Toxicology, Vol. 46, Issue 9 (Nov 2008), 908 – 910

Veterinary antibiotics in suspensions of vegetable oil such as cottonseed oil are in common use around the world. There are several reports of accidental human inoculation of oil-based veterinary vaccines that have required surgical debridement.

CASE REPORT: A 35 year old farmer injected an unknown quantity of Excenel RTU into her right thigh. Despite early debridement she developed a deep infection and recurrent chronic inflammation in the subcutaneous tissues and muscle secondary to the cottonseed oil suspension. Radical debridement and extensive split skin grafting was required but she still has had recurrences 12 months after injury.

DISCUSSION: Prompt surgical debridement should be performed as in cases of oil based veterinary vaccines. Despite being an antibiotic there is a significant risk of infection from a dirty needle following inoculation and multiple cultures should be taken and appropriate broad spectrum antibiotics used.

Accidental human injection of Excenel RTU: ceftiofur hydrochloride in cottonseed oil

Gwynne-Jones,D.; Lyall,P.; Hung,N.A.; Meikle,G.
Clinical Toxicology, Vol. 46, Issue 9 (Nov 2008), 908 – 910

Veterinary antibiotics in suspensions of vegetable oil such as cottonseed oil are in common use around the world. There are several reports of accidental human inoculation of oil-based veterinary vaccines that have required surgical debridement.

CASE REPORT: A 35 year old farmer injected an unknown quantity of Excenel RTU into her right thigh. Despite early debridement she developed a deep infection and recurrent chronic inflammation in the subcutaneous tissues and muscle secondary to the cottonseed oil suspension. Radical debridement and extensive split skin grafting was required but she still has had recurrences 12 months after injury.

DISCUSSION: Prompt surgical debridement should be performed as in cases of oil based veterinary vaccines. Despite being an antibiotic there is a significant risk of infection from a dirty needle following inoculation and multiple cultures should be taken and appropriate broad spectrum antibiotics used.

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