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Pesticide exposure and lymphoid neoplasms

Posted May 08 2009 11:39pm

Investigating the relationship between occupational exposure to pesticides and the risk of lymphoid neoplasms (LNs) in men in a hospital based case-control study in France. The results are based on case-by-case expert review of occupation-specific questionnaires. They support the hypothesis that occupational pesticide exposures may be involved in Hodgkin’s lymphoma , multiple myeloma and hairy-cell leukaemia and do not rule out a role in non-Hodgkin’s lymphoma . The analyses identified specific pesticides that deserve further investigation and the findings were consistent with those of previous studies.

Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control study
Orsi, L, Delabre, L, Monnereau, A, Delval, P, Berthou, C, Fenaux, P, Marit, G, Soubeyran, P, Huguet, F, Milpied, N, Leporrier, M, Hemon, D, Troussard, X, Clavel, J Occupational and Environmental Medicine 2009; 66:291-298

Methods:
A hospital-based case-control study was conducted in six centres in France between 2000 and 2004. The cases were incident cases with a diagnosis of lymphoid neoplasms aged 18-75 years. During the same period, controls of the same age and sex as the cases were recruited in the same hospital, mainly in the orthopaedic and rheumatological departments.

Exposures to pesticides were evaluated through specific interviews and case-by-case expert reviews. Four hundred and ninety-one cases (244 cases of non-Hodgkin’s lymphoma (NHL), 87 of Hodgkin’s lymphoma (HL), 104 of lymphoproliferative syndromes (LPSs) and 56 of multiple myeloma (MM) cases) and 456 controls were included in the analyses. The odds ratios (ORs) and 95% CI were estimated using unconditional logistic regressions.

Results:
Positive associations between HL and occupational exposure to triazole fungicides and urea herbicides were observed (OR = 8.4 (2.2 to 32.4), 10.8 (2.4 to 48.1), respectively).

Exposure to insecticides, fungicides and herbicides were linked to a threefold increase in MM risk (OR = 2.8 (1.2 to 6.5), 3.2 (1.4 to 7.2), 2.9 (1.3 to 6.5)).

For LPS subtypes, associations restricted to hairy-cell leukaemia (HCL) were evidenced for exposure to organochlorine insecticides, phenoxy herbicides and triazine herbicides (OR = 4.9 (1.1 to 21.2), 4.1 (1.1 to 15.5), 5.1 (1.4 to 19.3)), although based on small numbers.

Lastly, despite the increased ORs for organochlorine and organophosphate insecticides, carbamate fungicides and triazine herbicides, no significant associations were evidenced for NHL.

Posted in Chemical agents, Occupational cancer Tagged: cancer, pesticides
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