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Mold and damp work spaces may cause new-onset adult asthma

Posted Mar 11 2010 10:23am

Damp and moldy indoor environments aggravate pre-existing asthma, but may also induce new-onset asthma. Finnish researchers assessed the probability of molds being the cause of asthma in a series  of 694 patients examined because of respiratory symptoms in relation to workplace dampness and molds between 1995 and 2004. They had all been exposed to molds at work and had suffered from work-related lower respiratory symptoms.  

Using internationally recommended diagnostic criteria for occupational asthma (OA), they categorized the patients into three groups: probable, possible, and unlikely OA (156, 45, and 475 patients, respectively). In the group of probable OA, mold sensitization was found in 20%. The level of exposure and sensitization to molds was associated with probable OA. Exposure to damp and moldy workplaces can induce new-onset adult asthma. IgE mediation is a rare mechanism, whereas other mechanisms are unknown.

New-onset adult asthma in relation to damp and moldy workplaces
Kirsi Karvala1 et al. International Archives of Occupational and Environmental Health 0340-0131 (Print) 1432-1246 (Online) February 02, 2010

Abstract

Objective: Damp and moldy indoor environments aggravate pre-existing asthma. Recent meta-analyses suggest that exposure to such environments may also induce new-onset asthma. We assessed the probability of molds being the cause of asthma in a patient series examined because of respiratory symptoms in relation to workplace dampness and molds.

Methods:  Altogether 694 such patients had been clinically assessed between 1995 and 2004. According to their histories, they had all been exposed to molds at work and had suffered from work-related lower respiratory symptoms. The investigations had included specific inhalation challenge (SIC) tests with mold extracts and serial peak expiratory flow (PEF) recordings. Using internationally recommended diagnostic criteria for occupational asthma (OA), we categorized the patients into three groups: probable, possible, and unlikely OA (156, 45, and 475 patients, respectively). The clinical details of 258 patients were analyzed, and their levels of microbial exposure were evaluated.

Results: The agreement between the serial PEF recordings and SIC tests (both being either positive or negative) was 56%. In the group of probable OA, mold sensitization was found in 20%. The level of exposure and sensitization to molds was associated with probable OA. At 6 months, the follow-up examinations of 136 patients with probable OA showed that the symptoms were persistent, and no improvement in spirometry was noted despite adequate treatment. Only 58% of the patients had returned to work.

Conclusions: Exposure to damp and moldy workplaces can induce new-onset adult asthma. IgE mediation is a rare mechanism, whereas other mechanisms are unknown.


Filed under: Asthma , Biological agents , No category , Physical agents Tagged: Mold , Occupational asthma
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