A new allergen in the pharmaceutical industry
Jungewelter S, Aalto-Korte K. Section of Dermatology, Finnish Institute of Occupational Health (FIOH), Case Report
Worker: 26 year old pharmaceutical worker, no history of atopic disease is working on the synthesis of flutaminde, an anti-androgen drug used in the treatment of prostatic cancer.
Symptoms: pruritis, erythema of face, upper thorax and neck
Timeframe: pruritis after 1 hr, erythema after 3 hrs, lasting 3 days.
Strong allergic reaction in skin prick test with N-(3-trifluoromethyl-4-nitrophenyl)phthalimide.
Occupational allergic contact dermatitis from N-(3-trifluoromethyl-4-nitrophenyl)phthalimide, an intermediate in the production of flutamide.
This allergy was not reported previously. There are several reports on cutaneus photosensitivity reactions in patients taking flutamide for prostate carcinoma.