Splicing and dicing telomerase RNAby
Dr. Chris P.
, a startling new study reveals that telomerase RNA is processed by the mRNA splicing machinery. From Box et al.:
Spliceosomal cleavage generates the 3′ end of telomerase RNA
elomeres cap the ends of chromosomes and provide...
siRNA, NMD, and tumor antigen expression in cancerby
Dr. Arnon Krongrad
has shown only that is is possible in the laboratory to inhibit so-called “nonsense-mediated messenger RNA decay” (NMD) through the use of small interfering RNA (siRNA) molecules. Such inhibition of NMD in tumor cells led to the expression...