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A Novel Immortalized Human Adrenal Cell Line with Inactive Protein Kinase A for Studies on cAMP Signaling and Endocrine Tumorige by nih.gov Description of Invention: The first known immortalized cell line with a naturally-occurring inactivating mutation in PRKAR1A, the regulatory subunit type 1A (R1alpha) of protein kinase...
Modulating P38 Kinase Activity by nih.gov Description of Invention: Protein kinases are involved in various cellular responses to extracellular signals. The protein kinase termed p38 is also known as cytokine suppressive anti-inflammatory...
Over-expression and Mutation of a Tyrosine Kinase Receptor FGFR4 in Tumors by nih.gov Over-expression and Mutation of a Tyrosine Kinase Receptor FGFR4 in Tumors. Please contact John D. Hewes, Ph.D....
Tyrosine Kinase Disorder Seminar, PBL, and POD by CCLCM Student .. Medical Student Our seminar this morning was pretty good. We were divided up into four groups of eight, and the seminar was led by a hematologist along with an immunologist. He made the seminar a lot more clinically-oriented than most of
Genetics Home Reference: phosphoglycerate kinase deficiency by nih.gov December 2011 What is phosphoglycerate kinase deficiency? Phosphoglycerate kinase deficiency.... The other form of phosphoglycerate kinase deficiency is often called the myopathic form. It primarily affects...
Researchers Identify Proteins that Help Hepatitis C Virus Enter Liver Cells by Cancer.gov . Both proteins are a type of molecule called receptor tyrosine kinases. Anticancer drugs called tyrosine kinase... inhibitory RNAs to block several kinase proteins one by one. They found that silencing the expression of two...
Genetics Home Reference: mevalonate kinase deficiency by nih.gov  ; injury  ; joint  ; kidney  ; kinase  ; lymph  ; lymph node  ; mutation  ; protein  ; recessive... Reviewed April 2011 What is mevalonate kinase deficiency? Mevalonate kinase deficiency...
Antisera to Detect Phosphorylated Phosphoinositide-Dependent Kinase 1 (PDK-1) by nih.gov -dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop. J Biol... kinases, and plays a major role in insulin and growth factor signaling. PDK-1 also represents a promising...
Janus Family Kinases (JAK) And Identification Of Immune Modulators by nih.gov the JAK-3 protein. JAK-3 is a protein tyrosine kinase having a molecular weight of approximately 116 kDa... in resting T cells. The JAK-3 protein itself, antibodies to this protein, and methods of identifying...
AMP-activated kinase, a target of exercise mimetics, may contribute to photoaging and cell death by Dr. Chris P. Doctor of Philosophy to UV-induced apoptosis in the skin. From Cao et al.: AMP-activated protein kinase contributes to UV- and H 2 O 2 -induced apoptosis in human skin keratinocytes AMP-activated protein kinase or AMPK...

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