This is a question that can only be answered with "ideas" of the what may have caused this. Without a necropsy done on the dead pups you will never know for sure. The necropsy may not even be definitive...
News: Topamax May CauseBirth Defectsby
Connection. Please check it out: Topamax May CauseBirth Defects. Also, Marijke over at Help My Hurt did an article about it too: Epilepsy and Migraine Drug Topamax Investigated for Birth Defects.
Do ADHD Medications CauseBirth Defects?by
ADHD Medications and Pregnancy
Do ADHD Medications CauseBirth Defects?
Due to the impulsive... such as Tourette's Syndrome), is also less likely to causebirth defects than stimulants. Clonidine, which also goes...