Non-Invasive Treatment for Morbid Obesity and Type II Diabetes? EndoBarrier
Posted Oct 23 2008 9:11pm
Upon first glance, ( even if it looks like barbed wire and a condom ) this seems like a possible future alternative to the traditional Roux-en-Y gastric bypass surgery yet it gives similar results, but IT CAN BE REVERSED ENTIRELY, and does not require the permanent destruction of vital intestine:
"The EndoBarrier™ is a gastrointestinal liner that
acts as an impermeable barrier to prevent food from coming in contact
with the wall of the intestine. This may have an effect on the
patient's uptake of both nutrients and calories. It may also have a
metabolic effect that is similar to Roux-en-Y gastric bypass surgery,
which produces significant weight loss and resolution of type 2
diabetes. However, the EndoBarrier™ is placed and removed
endoscopically. As with many endoscopic procedures, the EndoBarrier™
may provide a safer alternative with more rapid recovery and lower
costs."
Some of the "features sold:"
May mimic the metabolic effects of Roux-en-Y gastric bypass
Performed as a day procedure
Delivered and removed endoscopically
Is a reversible procedure
Metabolic weight loss and control of type 2 diabetes
Minimizes potential for morbidity and mortality of traditional surgery
Is less invasive than surgical alternatives
Eliminates hospital stays
Food bypasses the duodenum and proximal jejunum as it does in a Roux-en-Y Gastric Bypass
Although - there were issues in this trial:
"... the sleeve came loose and began migrating in three patients. In all
cases, it was successfully retrieved through endoscopy.
Other
adverse events included 8 cases of abdominal pain, three cases each of
diarrhea and vomiting, two incidents of hypoglycemia, and one of nausea."
Ouch. So maybe the barbed wire isn't 100% yet. They'll get it right.
And, so some of the side effects are the same - looks like dumping and reactive hypoglycemia would still exist if you coat the upper intestine with a sheath - but it's temporary with a procedure like this (unless it's meant to STAY in forever?)
Which means you might not develop a condition like nesidioblastosis? If you were to develop it - that is.
Upon first glance, ( even if it looks like barbed wire and a condom ) this seems like a possible future alternative to the traditional Roux-en-Y gastric bypass surgery yet it gives similar results, but IT CAN BE REVERSED ENTIRELY, and does not require the permanent destruction of vital intestine:
- Some of the "features sold:"
- May mimic the metabolic effects of Roux-en-Y gastric bypass
- Performed as a day procedure
- Delivered and removed endoscopically
- Is a reversible procedure
- Metabolic weight loss and control of type 2 diabetes
- Minimizes potential for morbidity and mortality of traditional surgery
- Is less invasive than surgical alternatives
- Eliminates hospital stays
Food bypasses the duodenum and proximal jejunum as it does in a Roux-en-Y Gastric Bypass
Although - there were issues in this trial:Ouch. So maybe the barbed wire isn't 100% yet. They'll get it right.
And, so some of the side effects are the same - looks like dumping and reactive hypoglycemia would still exist if you coat the upper intestine with a sheath - but it's temporary with a procedure like this (unless it's meant to STAY in forever?)
Which means you might not develop a condition like nesidioblastosis? If you were to develop it - that is.
Right?
I have lots of questions.
http://www.medpagetoday.com/MeetingCoverage/ADAMeeting/tb/9759
Interim Report on a Prospective, Randomized Sham Controlled Trial Investigating a Completely Endoscopic Duodenal-Jejunal Bypass Sleeve for the Treatment of Type 2 Diabetes