Great. * Pops Another 50,000 IU Vitamin D Capsule * This study refers to the male species. But, I have a Vitamin D level of 12. So. I will continue on.
-B
________________________________________________________________________________
Source
- Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men. A prospective study. Arch Intern Med. 2008;168:1174-1180.
The study, published in the June 9, 2008 issue of the Archives of Internal Medicine,
found that low levels of 25-dihydroxyvitamin-D (25[OH]D) were
associated with a higher risk of myocardial infarction (MI) in a graded
manner, even after researchers controlled for factors known to be
associated with coronary artery disease.
Relative risk of nonfatal MI/fatal CHD in men with low levels of 25(OH)D vs those with levels > 30 ng/mL
| Level of plasma 25(OH)D at baseline | < 15.0 ng/mL | 15.1 - 22.5 ng/mL | 22.6 - 29.9 ng/mL | > 30.0 ng/mL | p for trend |
| Cases/controls (n) | 63/87 | 156/307 | 165/299 | 70/207 | NA |
| Analysis 1 (RR, 95% CI) a | 2.42 (1.53 - 3.84) | 1.65 (1.15 - 2.37) | 1.72 (1.22 - 2.42) | 1 | < 0.001 |
| Analysis 2 (RR, 95% CI) b | 2.09 (1.24 - 3.54) | 1.43 (0.96 - 2.13) | 1.60 (1.10 - 2.32) | 1 | 0.02 |
Giovannucci et al emphasize that men with circulating 25(OH)D levels
of at least 30 ng/mL had approximately half the risk of MI, independent
of other cardiovascular risk factors, and this association was
suggestively stronger for fatal CHD, although the number of cases was
too small to make definitive conclusions.
They note that only 23%
of the men in the HPFS had levels of 25(OH)D of at least 30 ng/mL,
which is typical of many populations, and the prevalence of deficiency
is even higher in subpopulations such as dark-skinned individuals and
elderly persons. In individuals in sun-rich environments, where
clothing or cultural practices do not appreciably limit vitamin-D
production, 25(OH)D levels of 54 to 90 ng/mL are attained, they report,
adding that it is not possible from these data to evaluate whether
levels greater than 35 ng/mL would be associated with an even greater
MI risk reduction.
While vitamin-D supplementation was not shown to affect cardiovascular risk in the Women's HealthInitiative,
the authors point out that the range of vitamin-D levels was much
narrower in that study, which would have made it more difficult to
detect any effect. They say that to increase 25(OH)D levels from 12 to
35.5 ng/mL would require approximately 3000 IU of vitamin D daily, and
although such intakes may seem high by current standards, increasing
evidence demonstrates no toxic effects at intakes below 10,000 IU/day.
Because current sources of vitamin D provide much less (eg, a glass of
milk has approximately 100 IU), those who achieve high levels such as
35 ng/mL naturally do so largely through sun exposure, they add.
Great. * Pops Another 50,000 IU Vitamin D Capsule * This study refers to the male species. But, I have a Vitamin D level of 12. So. I will continue on.
-B
________________________________________________________________________________
Source
The study, published in the June 9, 2008 issue of the Archives of Internal Medicine, found that low levels of 25-dihydroxyvitamin-D (25[OH]D) were associated with a higher risk of myocardial infarction (MI) in a graded manner, even after researchers controlled for factors known to be associated with coronary artery disease.
Relative risk of nonfatal MI/fatal CHD in men with low levels of 25(OH)D vs those with levels > 30 ng/mL
Giovannucci et al emphasize that men with circulating 25(OH)D levels of at least 30 ng/mL had approximately half the risk of MI, independent of other cardiovascular risk factors, and this association was suggestively stronger for fatal CHD, although the number of cases was too small to make definitive conclusions.
They note that only 23% of the men in the HPFS had levels of 25(OH)D of at least 30 ng/mL, which is typical of many populations, and the prevalence of deficiency is even higher in subpopulations such as dark-skinned individuals and elderly persons. In individuals in sun-rich environments, where clothing or cultural practices do not appreciably limit vitamin-D production, 25(OH)D levels of 54 to 90 ng/mL are attained, they report, adding that it is not possible from these data to evaluate whether levels greater than 35 ng/mL would be associated with an even greater MI risk reduction.
While vitamin-D supplementation was not shown to affect cardiovascular risk in the Women's HealthInitiative, the authors point out that the range of vitamin-D levels was much narrower in that study, which would have made it more difficult to detect any effect. They say that to increase 25(OH)D levels from 12 to 35.5 ng/mL would require approximately 3000 IU of vitamin D daily, and although such intakes may seem high by current standards, increasing evidence demonstrates no toxic effects at intakes below 10,000 IU/day. Because current sources of vitamin D provide much less (eg, a glass of milk has approximately 100 IU), those who achieve high levels such as 35 ng/mL naturally do so largely through sun exposure, they add.