Hypervitaminosis! . Hypervitaminosis is the medical term for getting sick from taking too much of a vitamin -- but how sick you can get and how much you have to take to get sick varies all over the map, depending on the vitamin. The fat soluble vitamins are the ones to watch out for, especially vitamin A and vitamin D. The water soluble vitamins (such as C and B-complex) are less dangerous, as they do not build up in your system over time.
For example, prominent researchers have promoted massive doses of Vitamin C as a means of preventing colds and cancer (though the last time I looked, there was no good evidence this worked). But it points out that it is pretty hard to get sick from taking vitamin C. By contrast, taking too many capsules of vitamin A daily can lead to serious and even life threatening illnesses (if you take more than 25,000 IU/day). Hypervitaminosis A makes your long bones hurt, causes your skin to defoliate, and can damage your liver, among other unpleasant effects.
The other fat-soluble vitamins include D, E, and K.
Too much vitamin D will make your Calcium level rise, and give you kidney stones -- but it takes 100 times the daily recommended dosage over an extended period of time.
Vitamin E also is a concern, but studies have focused on whether a high daily dose over a long time will be a risk factor for other conditions, such as heart disease. In practice, few people have become sick from vitamin E.
Vitamin K is required for your liver to make coagulation factors. Not enough can make you bleed too easily. Too much is not a problem, unless you are taking a medicine to thin the blood (an anti-coagulant), such as warfarin (Coumadin).
Finally, the supplement that can be even more dangerous than vitamins is Iron! Supplemental Iron (ferrous sulfate or ferrous gluconate) is toxic in moderate doses. In fact, when larger dosage forms were available over the counter, there used to be tens of deaths per year, especially among children, due to accidental overdosage on iron pills that looked too much like candy. The maximum daily dose for the increased needs of a pregnant woman is 30mg, and that is the most that you can get in an over the counter iron supplement. The pills that are given on prescription for people with anemia (low blood count) who need to rebuild their iron stores have 300mg of ferrous sulfate -- but a handful of the 300 mg pills can make you acutely ill, with vomiting and diarrhea, and other nasty effects (up to and including death if you have a big handful).
The bottom line is that several multivitamins per day probably won't do any harm -- but I'm not sure I see any good reason to take more than one.
Geoff Rutledge, MD
Posted by Nirmala N.
Is it possible to overdose on your vitamins? In general, how much is too much? Is taking several supplements on top of your multivitamin potentially hazardous to your health?