Find out which Vegetables can Repair DNA and help fight Cancer
Posted Oct 01 2008 5:07pm
For many decades, science has been focused on understanding themechanisms of disease so that drugs could be developed. But thecloser they look at disease, the more they discover thepowerful and protective nature of whole foods.In a new study published in the "British Journal ofCancer" and by the journal "Nature" the researchers show that inlaboratory tests, a compound called indole-3-carinol (I3C), foundin broccoli, cauliflower and cabbage, and a chemical calledgenistein, found in soy beans, can increase the levels of twospecific proteins that repair damaged DNA.This study is one of the first to provide a molecular explanationas to how eating vegetables could cut the risk of developingcancer, an association that some population studies have found,says the study's senior author, Eliot M. Rosen, MD, PhD,professor of oncology, cell biology, and radiation medicine atGeorgetown 's Lombardi Comprehensive Cancer Center . "It is nowclear that the function of crucial cancer genes can be influencedby compounds in the things we eat," Rosen says."Our findings suggest a clear molecular process that wouldexplain the connection between diet and cancer prevention."In this study, Rosen exposed breast and prostate cancer cellsto increasing doses of I3C and genistein, and found thatthese chemicals boosted production of the repair proteinsBRCA1 and BRCA2.Since decreased amounts of the BRCA proteins are seen in cancercells, higher levels might prevent cancer from developing, Rosenspeculates, adding that the ability of I3C and genistein toincrease production of BRCA proteins could explain theirprotective effects.