Studies have shown that SAMe shapes the formation of brain chemicals and helps in the preservation of glutathione, a key antioxidant. In addition, SAMe is involved in the development of myelin, the white sheath surrounding nerve cells. Most people who take SAMe notice an increase in concentration, vitality, energy, and wellbeing. The effects of SAMe on depression have been tested in a number of studies. In 1994, researchers at the University of California, Irvine Medical Center, conducted a double-blind randomized trial involving a total of twenty-six patients. They compared oral SAM with oral desipramine (a pharmaceutical antidepressant). At the end of the four-week period, 62% ofpatients treated with SAMe and 50 percent of the patients treated with desipramine had significantly improved.