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How Chronic Stress Can Harm You – Neural Network Repeating Same Dysfunctional Behavior and Hoping for a Different Outcome

Posted Jul 19 2012 4:45pm

I always think of our bodies as living, breathing pin ball machines. One thing – a thought, emotion, physical injury or illness pops that little speeding ball up and over the arc of our life . . . and then continues bouncing off and triggering problems in all other areas, physical and emotional, triggering continuous stories, problems, issues, and in this case, “chronic stress.”


Chronic stress is the response to emotional pressure suffered for a prolonged period over which an individual perceives he or she has no control.  It involves an endocrine system response in which occurs a release of corticosteroids.

Corticosteroids are a class of chemicals that includes steroid hormones naturally produced in the adrenal cortex of vertebrates. Corticosteroids are involved in a wide range of physiologic processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.

What you really need to know . . . is that if chronic stress continues for a long time, it can cause damage to an individual’s physical and mental health pin balling off all areas of life, work, relationships, dreams, goals, passion and purpose. 

From article by Dr. David Perlmutter and Dr. Alberto Villoldo.

From an engineering standpoint, stress can be defined as the amount of resistance a material offers to being reshaped and reformed. When you place a load on a steel beam, the beam resists, keeping the building from collapsing. If the load is great enough, the beam gives way and the structure suffers damage or collapses. Psychological stress is similar. When we can no longer resist forces that are trying to shape and mold us, whether they are our spouse’s behavior or our nation’s economic decline, we break down, becoming anxious and depressed, unable to cope.



The stress hormone cortisol, which is produced in excessive amounts when the hypothalamic-pituitary-adrenal axis (HPA axis) is locked in a state of chronic stress, increases the damaging effects of free radicals in the neurons of the hippocampus. This causes damage to the mitochondria, which in turn causes even more free radical production. The final act in this tragic play is that the hippocampal neurons themselves perish through the process of apoptosis. And when hippocampal neurons die, learning and creativity become almost impossible—and brain synergy is out of the question.


The avoidance of pain overshadows natural curiosity; we hesitate to rock the boat; we hoard needlessly and risk foolishly. We become paralyzed by an inability to discover novel solutions and are unable to think or feel originally anymore. If we remain under acute stress long enough, our adrenals eventually give out and we become drained and exhausted.


In a 2009 study, “Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making,” Eduardo Dias-Ferreira and his colleagues at the University of Minho in Braga, Portugal, demonstrated that chronically stressed rats lose their ability to break out of repetitive behavior patterns and become less creative and less cunning. Essentially, stress changes the rodents’ behavior, predisposing the animals to doing the same things over and over.

“This is a great model for understanding why we end up in a rut, and then dig ourselves deeper and deeper into that rut,” Robert Sapolsky, a neurobiologist who studies stress at Stanford University School of Medicine, told The New York Times in 2009. “We’re lousy at recognizing when our normal coping mechanisms aren’t working.”

Chronic stress can lead to a rut in which the wiring of our neural networks keeps us repeating the same dysfunctional behavior and hoping for a different outcome.



As we experience depression and repetitive behaviors that stem from chronic stress, we’re less capable of analytic thought. The stress hormones released into the bloodstream keep us at a lower order of brain function, unable to attain synergy. Like iron and carbon, we remain brittle and easily afflicted, unable to find the strength of steel. We find it increasingly difficult to learn from past experiences, to alter the beliefs that cause us to recreate those experiences again and again, and to break out of our behavioral ruts.

Because of the way our brains have been wired by stress and trauma, we’re unable to think or feel our way out of personal crises.



To protect against the damage of chronic stress is to change the hippocampus set-point. As research continued to expose the connection between cortisol production and hippocampal damage, scientists began to wonder what actually controlled the amount of cortisol produced by the adrenal glands during a stressful event. It has long been recognized, for example, that not only do older humans and animals alike generally have higher levels of cortisol, but the degree of cortisol production following stress also seems to increase with age.

Great efforts have been made to find the “pacemaker” for the adrenal gland. Scientists reasoned that if such a structure indeed existed in the human body, perhaps there is also a way to control excess cortisol production. In this way, the damage to the hippocampus that occurs during normal aging—and at a much faster rate in Alzheimer’s patients—could be reduced.


1: If we remain under acute stress long enough, our adrenals eventually give out and we become drained and exhausted.

2: Chronic stress can lead to a rut in which the wiring of our neural networks keeps us repeating the same dysfunctional behavior and hoping for a different outcome.

3: When hippocampal neurons die, learning and creativity become almost impossible.

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