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In addition to antioxidant application, specific micronutrients, including vitamins and vitamin derivatives, have been deemed invaluable for nourishing skin and protecting against radiation dermatitis. Moreover, micronutrient deficiency actually mimics radiation damage by causing DNA single- and double-strand breaks and oxidative lesions in normal skin cells. Supplementing micronutrients via the topical application of vitamin precursors and vitamin derivatives protects against radiation-induced skin injury. Accordingly, retinyl palmitate, the precursor to retinoic acid and a biological form of vitamin A, has been shown to prevent radiation-induced DNA damage and erythema in normal skin cells. The topical application of retinyl palmitate counteracts vitamin A depletion caused by radiotherapy and promotes recovery. Retinyl palmitate also helps treat radiation-induced skin ulcerations by nourishing the migratory epithelial cells responsible for closing the wound. Overall, retinyl palmitate has been found to increase radiation’s effect on tumor cells in vivo, while decreasing symptoms associated with radiation dermatitis.
Ascorbyl palmitate is another important vitamin derivative that nourishes human skin and helps prevent radiation dermatitis. The micornutrient is a lipid-soluble derivative of ascorbic acid capable of penetrating the stratum corneum to target sites of cell-signaling pathways that are not accessible to water-soluble molecules. Ascorbyl palmitate has been found to maintain tissue integrity while protecting against erythema and desquamation via its potent moisturizing effect. Furthermore, ascorbyl palmitate is an effective free radical scavenger and guards well against radiation-induced DNA damage in epithelial cell lines. Ascorbyl palmitate may play a critical role in preventing radiation-induced tissue damage by providing proper cell nourishment and antioxidative protection.
Cholecalciferol (CF), or vitamin D 3, is hydroxylated in the kidney to produce 1,25-dihydroxyvitmain D, which is an active metabolite and hormone that sustains proper cell function by binding to vitamin D receptors. In particular, the derivative demonstrates strong immunoreactivity in skin and hair follicle vitamin D receptors, thereby protecting against radiation toxicity and preventing radiation dermatitis. The topical application of certain micronutrients and subsequent uptake by the stratum corneum, epidermis and dermis, has a synergistic effect with radiotherapy. Altogether, CF, ascorbyl palmitate and retinyl palmitate have been shown to increase tumor response during radiation treatment while protecting against radiation dermatitis.
For more information please visit:
www.mccordresearch.com
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www.articlesbase.com/authors/darlene-mccord/58998.htm
darlenemccord.blogspot.com
darlenemccord.wordpress.com
darlenemccord.blog.com
In addition to antioxidant application, specific micronutrients, including vitamins and vitamin derivatives, have been deemed invaluable for nourishing skin and protecting against radiation dermatitis. Moreover, micronutrient deficiency actually mimics radiation damage by causing DNA single- and double-strand breaks and oxidative lesions in normal skin cells. Supplementing micronutrients via the topical application of vitamin precursors and vitamin derivatives protects against radiation-induced skin injury. Accordingly, retinyl palmitate, the precursor to retinoic acid and a biological form of vitamin A, has been shown to prevent radiation-induced DNA damage and erythema in normal skin cells. The topical application of retinyl palmitate counteracts vitamin A depletion caused by radiotherapy and promotes recovery. Retinyl palmitate also helps treat radiation-induced skin ulcerations by nourishing the migratory epithelial cells responsible for closing the wound. Overall, retinyl palmitate has been found to increase radiation’s effect on tumor cells in vivo, while decreasing symptoms associated with radiation dermatitis.
Ascorbyl palmitate is another important vitamin derivative that nourishes human skin and helps prevent radiation dermatitis. The micornutrient is a lipid-soluble derivative of ascorbic acid capable of penetrating the stratum corneum to target sites of cell-signaling pathways that are not accessible to water-soluble molecules. Ascorbyl palmitate has been found to maintain tissue integrity while protecting against erythema and desquamation via its potent moisturizing effect. Furthermore, ascorbyl palmitate is an effective free radical scavenger and guards well against radiation-induced DNA damage in epithelial cell lines. Ascorbyl palmitate may play a critical role in preventing radiation-induced tissue damage by providing proper cell nourishment and antioxidative protection.
Cholecalciferol (CF), or vitamin D 3, is hydroxylated in the kidney to produce 1,25-dihydroxyvitmain D, which is an active metabolite and hormone that sustains proper cell function by binding to vitamin D receptors. In particular, the derivative demonstrates strong immunoreactivity in skin and hair follicle vitamin D receptors, thereby protecting against radiation toxicity and preventing radiation dermatitis. The topical application of certain micronutrients and subsequent uptake by the stratum corneum, epidermis and dermis, has a synergistic effect with radiotherapy. Altogether, CF, ascorbyl palmitate and retinyl palmitate have been shown to increase tumor response during radiation treatment while protecting against radiation dermatitis.
For more information please visit:
www.mccordresearch.com
www.darlenemccord.com
www.corneotrophism.com
www.olivamine.com
www.darlene-mccord.com