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What is an Endometrial Biopsy?

Posted Nov 11 2009 10:00pm

Mock Cycle/Endometrial Biopsy

In order to assess the uterus for implantation an endometrial biopsy may be performed on a mock cycle.

Purpose: Assure normal uterine development for Embryo implantation

Endometrial Biopsy


The uterine lining, or endometrium, undergoes a specific sequence of changes after ovulation during the luteal phase of the menstrual cycle in order to develop a receptive environment for the developing embryo.   Estrogen followed by progesterone secretion by the ovaries is crucial for the proper development of the lining.   Abnormalities of uterine lining development, or luteal phase defects, may be documented with an endometrial biopsy.   The may be associated with abnormal implantation.

Patient Protocol

1. Call the office with the onset of menses.

2. Call the office to schedule the biopsy 18 days later.

What to Expect

The biopsy is somewhat like a pap smear.   After introducing a speculum into the vagina, the cervix will be wiped with betadine to cleanse it.   A small catheter is then introduced into the cervix and the biopsy is performed.   It takes a few seconds.   If you would like, you may take some Anaprox or your RE can give you a local anesthetic.

Most patients tolerate the procedure well and feel it is similar to the HSG.

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