The blue screen of death....or in the world of Mac computers...the gray screen of death with the question mark folder. These two phenomenon are terrifying for those of us dependent upon computers on a daily basis. Last week my college-aged son called us with the news that his MacBook Pro was giving him this problem. So naturally we all jumped into the mini-van and raced up Route 95 to his rescue! In our computer based world we are all on that razor's edge between happy computing and disaster!
In Natural Cycle IVF we are always on the razor's edge between wanting the follicle big enough to have a mature egg but not so big that there is an LH surge and the cycle gets canceled. In stimulated cycle IUI, an early LH surge is not such a big deal unless the follicles really were too small and the eggs immature. So what can one do about premature LH surge...well that is the topic of today's Question of the Day from 100 Questions and Answers about Infertility.
43. My doctor wants to use Lupron or Antagon during my IUI cycle. What are these drugs, and why do I need them? I thought they were only for IVF.
Lupron and Antagon are injectible medications that are used to prevent premature release of LH hormone during a stimulation cycle for IUI or IVF. These two medications work through different mechanisms to prevent the LH surge. Lupron usually requires at least 7 days to effectively prevent an LH surge whereas Antagon works within hours. This difference explains why the drug protocols that employ these two medications are so different. Premature ovulation during an IUI cycle can be dealt with by simply adjusting the timing of the IUI, so these medications are primarily used in patients undergoing IVF rather than IUI. For most patients undergoing treatment with IUI unless a patient repeatedly experiences a premature LH surge during the treatment cycle. In such cases, these medications can allow for a more optimal stimulation and larger follicle sizes.