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Epithelial Cell Abnormalities

Posted Nov 14 2010 12:00am


This is one of the statements to indicate if the cells collected were normal or abnormal.

A. Squamous Cell Abnormalities
A.1 Atypical squamous cells (ASC). In this category, there are minor cell changes from unknown causes. It is further divided into two types A.1.1 ASC-US: ASC of undetermined significance
A.1.2 ASC-H: ASC that cannot exclude high- grade squamous intraephithelial lesion(HSIL).

A.2 Low-grade squamous intraepithelial lesions (LSIL). In this category, there are cells that show definite minor changes but are unlikely to progress to cancer. It includes the presence of human papillomavirus (HPV) infection, mild dysplasia, and cervical intraepithelial neoplasia (CIN 1).

A.3 High-grade squamous intraepithelial lesions (HSIL). In this category, there are cell changes that have a higher likelihood of progressing to cancer. It includes the presence of moderate to severe dysplasia, carcinoma in situ (CIS), CIN 2 and CIN 3, or changes suspicious for invasive cancer.

A.4 Squamous cell invasive cancer.


B. Glandular Cell Abnormalities
B.1 Atypical glandular cells (ACG) include:
B.1.1 Endocervical (from cervical canal) cells.
B.1.2Endometrial cells. These cells are normally found in the uterus. Their presence in the cervix might occur in menstruating women but would be abnormal in postmenopausal women who are not on hormonal replacement therapy.

B.2 Glandular cells.
B.2.1 Atypical glandular cells (neoplastic changes)
B.2.2 Endocervical cells
B.2.3 Glandular cells

B.3 Endocervical adenocarcinoma in situ (AIS)

B.4 Adenocarcinoma
B.4.1 Endocervical
B.4.2 Endometrial
B.4.3 Extrauterine
B.4.4 Other, not specified
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