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ProHeart 6: More About the Drug’s Dangers

Posted Mar 05 2009 2:15pm

Still considering giving your dog ProHeart 6 for heartworm protection? ProHearts’ own Client Information Form lists adverse reactions: “These can include (but are not limited to) allergic responses, lethargy (sluggishness), seizures, vomiting and diarrhea, itching at the injection site, fever and, in rare instances, death.” Read the entire form at (Note: To enlarge the print size, change it to “100%” on the toolbar underneath the word “Help.”)

An article from the FDA worth reading reports “the side effects…anorexia (loss of appetite); lethargy; vomiting; neurologic signs, such as seizures, difficulty walking and reports of blindness; jaundice (a yellowish appearance); and bleeding disorders. Most of these observable clinical signs have occurred within one month of receiving the drug.”

To comply with the FDA’s “risk minimization” plan, Fort Dodge is implementing an educational and communication program that will require veterinarians to register with Fort Dodge and complete “in-depth” training as a condition of purchasing ProHeart 6. A letter from the FDA explains vets will also have to “confirm they have completed the in-depth training, read the new label, the conditions of use, the requirements to provide the dog owner with the Client Information Sheet and obtain signed informed consent, record the product lot number in the medical record, and report adverse events. Veterinarians are also advised to obtain baseline history, physical exam, and blood-work parameters prior to administration of the drug to confirm the patient is an appropriate candidate for ProHeart 6.” Read the entire letter at

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