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Autism and Folic Acid: The Plot Thickens

Posted Feb 14 2013 11:22am
Folic acid might reduce the risk of autism?

According to  a study of 85,176 children born in Norway just published in the Journal of the American Medical Assocation, mothers who reported taking a folic acid supplement in the weeks surrounding conception were 39% less likely to have a child later diagnosed with autism. Only 0.1% of children whose moms popped folic acid pills had autism compared to 0.2% of the those whose mothers didn't. The link between an autism diagnosis and folic acid held up even after controlling for factors like maternal age and economic status. 

Curiosities

The link between folic acid and the milder forms of autism (Asperger's and Pervasive Developmental Disorder - Not Other Specified) did not remain significant and the authors argue it might be because they lacked enough subjects (i.e. statistical power). 

The study jibes with previous research suggesting folic acid reduces the risk of autism including a study of preschoolers in California.

Norway has a much lower rate of autism than the U.S. This study found .32% of children had an ASD diagnosis or compared to 1.14% of U.S. children. So for every 1,000 kids born in the respective countries, 3.2 receive an autism diagnosis in Norway compared to 11.4 in the U.S.

Suprise, surprise.  We have another surprised researcher:
"We were a bit surprised about how large the reduction in risk was and how it was specifically related to folic acid and not to other supplements," Pål Surén, MD, from the Norwegian Institute of Public Health in Oslo, told Medscape Medical News. More Evidence Prenatal Folic Acid May Lower Autism Risk, Medscape.
Add him to the list. I'm keeping count this year as per my request for Santa.  Not that I'm on counting a senior citizen who flies around the world in a magical sled to fix the media.

The study: JAMA. 2013;309(6):570-577. doi:10.1001/jama.2012.155925
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