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otavateam

Toronto, Canada
OTAVA Ltd. is an international science-based chemical company founded in 1997. Our company carries a diverse set of products and services for pharmaceutical companies, universities, research institutes and government agencies. We specialize in the development and production of building blocks, screening compounds, fluorescent dyes and kinase-related products, including various inhibitors and kinase focused libraries. Our facilities and highly-experienced personnel make possible a variety... Full Bio
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Seed Innovation Discovery Program (SIDP) from OTAVA by otavateam Posted in: Blog Posts in Healthcare Industry & Policy If your research is dedicated to the development of novel biologically active substances, new drug candidates or treatment strategies and you believe in creating true collab ... Read on »
Design your target-focused library with OTAVA by otavateam Posted in: Blog Posts in Healthcare Industry & Policy   The key goal during drug design process is to limit the number of compounds among large number of available ligands for experimental testing. For this purpose target-fo ... Read on »
Build up your compounds using chemical building blocks from OTAVA! by otavateam Posted in: Blog Posts in Healthy Living OTAVA specializes in synthesis and distribution of quality chemical building blocks. You could request custom synthesis of chemical compounds of your interest, for this purp ... Read on »
Chelator Fragment Library from OTAVA by otavateam Posted in: Blog Posts in Cancer Approximately half of all proteins contain metal ions in the active site for their biological activity. Metalloproteins are involved in many different cellular functions, su ... Read on »
Liver X Receptor β Agonists Library from OTAVA by otavateam Posted in: Blog Posts in Cancer Liver X receptors (LXRs) are ligand-activated transcription factors that belong to nuclear receptor superfamily. LXRs function as sterol sensors protecting cells from choles ... Read on »
DNA Methyltransferases DNMT1 and DNMT3b Target Focused Libraries from OTAVA by otavateam Posted in: Blog Posts in Complementary & Alternative Medicine DNA methylation is a major epigenetic modification which plays an important role in controlling gene expression, differentiation and embryonic development.This covalent modi ... Read on »
Tangible Screening Compounds from OTAVA by otavateam Posted in: Blog Posts in Healthy Living A tangible compound repository is a very important source of exclusive organic molecules for screening projects in drug discovery. Tangible compounds denote molecules that are ... Read on »
BRD4 Targeted Library for Drug Discovery by otavateam Posted in: Blog Posts in Healthy Living Bromodomain-containing Protein 4 (BRD4) is a key chromatin organizer that binds to acetylated histone lysine residues and regulates gene activation through transcription fac ... Read on »
DOT1L Histone H3 Methyltransferase Targeted Library for Drug Discovery by otavateam Posted in: Blog Posts in Health Education Histone methyltransferasesare promising epigenetic drug targets. Several drugs that inhibit histonemethyltransferases have been developed for anticancer therapy. DOT1L histon ... Read on »
Novel 5-Hydroxytryptamine Receptor (5-HT1B) Antagonists Library designed to achieve... by otavateam Posted in: Blog Posts in General Medicine 5-HT 1Bserotonin receptors are involved in regulation of several physiological functions, behavior and psychiatric diseases including locomotor activity, vascular smooth mus ... Read on »
Protein-Protein Interactions Focused Libraries for Drug Discovery by otavateam Posted in: Blog Posts in Diabetes Type 2 Protein-protein interactions (PPIs) are important in all aspects of cellular function and play a central role in developmentof different pathological conditions including ca ... Read on »
Otava Alzheimer’s Disease Targeted Libraries by otavateam Posted in: Blog Posts in Alzheimer's & Dementia Alzheimer’s disease (AD) is a devastating and always fatal neurodegenerative disorder characterized by progressive impairment of cognitive function and emotional disturbance ... Read on »
Central Nervous System (CNS) Compound Library from OTAVA by otavateam Posted in: Blog Posts in Alzheimer's & Dementia There are many different drug targets expressed in brain tissue.   The delivery of drugs to central nervous system (CNS) is complicated by blood brain barrier (BBB) which co ... Read on »
Lead-Like Library for Drug Discovery by otavateam Posted in: Blog Posts in Cancer The preclinical drug-discovery process requires the screening of millions of small organic molecules to find a suitable lead compound for one ultimately successful outcome. A ... Read on »
Biologically Active Molecules: Chemical Research, Development and Scale-up by otavateam Posted in: Blog Posts in Healthcare Industry & Policy The increasing demand for different biologically active molecules has posed challenges to the scientists to get the desired substances in large amounts either from natural sou ... Read on »
Search Otava Chemical Collections On-Line by otavateam Posted in: Blog Posts in Healthcare Industry & Policy In recent years, remarkable progress has been made and miraculous results produced in the field of synthetic chemistry.   However, searching for desired chemical compounds amo ... Read on »
OTAVA FRAGMENT-BASED LIBRARY by otavateam Posted in: Blog Posts in Genetics The challenging questionof the modern pharmaceutical industryis why do fragments hits provide a new paradigm for drug discovery of some targets?  In this white paper we descri ... Read on »
Otava HTS COMPOUND LIBRARIES by otavateam Posted in: Blog Posts in Genetics To identify promising leads for potentially marketable drugs requires large compound libraries.   In this white paper we would like to discuss some aspects of high-throughput ... Read on »
OTAVA FOCUSED LIBRARIES by otavateam Posted in: Blog Posts in Genetics Using special focused libraries of chemical compounds in drug design is becoming increasingly common.    Here we describe different kinds of focused compound librariesthat can ... Read on »
Otava Building Blocks by otavateam Posted in: Blog Posts in Genetics The objective of this report is to give some insight on usingchemical building blocks that allow generating diversity and complexity in chemical structures.Building blocks are ... Read on »