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Neurodoc .. Patient Expert

San Francisco, California
Blog: http://dementianotes.blogspot.com/
I am a practicing neurologist in Florida who blogs items I have read or studied recently for my own later use.  The public is free to read the blog  if it benefits them.  I post sporadically to six blogs, covering general neurology, dementia, behavioral neurology, stroke, multiple... Full Bio
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CSF profiles and variant dementia by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia Neurology 2012; 78:47 -54 CSF profiles of tau and abeta are extremely effective differentiating some dementias but not others. Markers were t(total) tau, p (phosphoryla ... Read on »
Brain reserve, education and Alzheimer's disease by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia Read on »
Vitamin D and risk of cognitive decline in elderly persons by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D; Archives of Internal Medicine 170 (13), 1135-41 (Jul 2010) BAC ... Read on »
Treating Neuropsychiatric Symptoms in Dementia With Lewy Bodies: A Randomized Co by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia Culo S, Mulsant BH, Rosen J, Mazumdar S, Blakesley RE, Houck PR, Pollock BG; Alzheimer Disease & Associated Disorders (Jul 2010) Sensitivity to psychotropic me ... Read on »
donepezil and apathy by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia Effect of donepezil on emergence of apathy in mild to moderate Alzheimer's disease; Waldemar G, Gauthier S, Jones R, Wilkinson D, Cummings J, Lopez O, Zhang R, Xu Y, Sun Y, ... Read on »
Cholinesterase inhibitor minutiae by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia 1.  oral donepezil is not affected by food, unlike rivastigmine and galanthamine 2.  donepezil has 3-5 hours to peak onnset v. 0.5-1 for galanthamine and rivastigmine (oral ... Read on »
GOVERNMENT REPORT ON RISK FACTORS FOR ALZ DISEASE by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia http://www.ahrq.gov/downloads/pub/evidence/pdf/alzheimers/alzcog.pdf   UPSHOT GOOD:  PHYSICAL ACTIVITY, COGNITIVE ENGAGEMENT BAD; SMOKING, E4 ALLELE, DI ... Read on »
Frontotemporal dementia- clinical pearls by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia 1.  Frontotemporal dementia is a clinical term, frontolobar degeneration is a pathologic term 2.  Preservation of memory, ability to keep track of day events, timing of s ... Read on »
Dementia classifications-- rapid FTD's, by abnormal protein by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia Frontotemporal dementia subtypes and genetics-- rapidly progressive subtypes 1. FTD and parkinsonism due to mutation on chromosome 17 on gene encoding microtubul ... Read on »
MAPT and types of tau by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia Patients with MAPT all have neuronal or glial tau inclusions, but phenotype can vary even among relatives with the disease.  Types include s Picks, s CBD, s PSP and s A ... Read on »
non sporadic or v CJD cases by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia There are more than 40 mutations, and most patients do not have a family history (although they may have a history of Alzheimer's or Parkinson's diseases). v CJD occurs in y ... Read on »
CJD Prion disease criteria by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia UCSF modified criteria (Geschwind) Rapid cognitive decline with any two (2) of 1. Myoclonus 2. Pyramidal/EP 3. Visual 4. Cerebellar 5. Akinetic mutism 6. Othe ... Read on »
Clinical syndromes associated with posterior cortical atrophy by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia Early age at onset AD spectrum. Migliaccio R, Agosta F et al. Neurology 2009; 1571-1578 Authors compared posterior cortical atrophy (PCA) and logopenic progressive apha ... Read on »
CSF markers tau and p-tau and low a Beta by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia NEUROLOGY 2009;72:1056-1061 17 patients (10%) with low levels of Aβ1-42 and very high levels of tau and p-tau. More with moderate levels of tau were found, plus controls ... Read on »
bv variant of FTD by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia NEUROLOGY 2009;72:732-737 Sensitivity of current criteria Consensus Criteria published in 1998 by Neary and colleagues. 4 Neary D, Snowden JS, Gustafson L, et al. Fro ... Read on »
CSF biomarkers and Alzheimer's disease by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia A. E. van der Vlies, MSc, N. A. Verwey, MD, F. H. Bouwman, MD, PhD, M. A. Blankenstein, PhD, M. Klein, PhD, P. Scheltens, MD, PhD and W. M. van der Flier, PhD CSF ... Read on »
Politics of health care reform distort reality by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia The October 29, 2009 issue of the New England Journal of Medicine contains four separate articles on health care issues which, if taken in their entirety, represent the ... Read on »
HIV dementia scales by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia HIV dementia scale http://www.hivguidelines.org/Content.aspx?PageID=325&guideLineID=44&guideParent=&vType=&pGuideLineID=44 , HIV modified dementia scale ht ... Read on »
neuropsychological predictors of poor driving in Alzheimer's disease by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia Benton Visual Retention Test Complex Figure Test Copy Trails A Functional Reach Test   from Neurology 2009 Feb Dawson et al. (Iowa) Read on »
lbd PEARLS by Neurodoc .. Patient Expert Posted in: Blog Posts in Alzheimer's & Dementia 1. RBD is common and fairly specific for synucleinopathy, LBD or MSA 2. Cognitive testing not that bad, memory not that bad, visuospatial especially copying is very bad ... Read on »
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