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Review: SPECT, MRI and Cognitive Dysfunction in Multiple Sclerosis

Posted Nov 17 2009 10:20pm
Posted in Medical Article Review, psychiatry by Dr Justin Marley on May 25, 2009

The featured article is ‘SPECT, MRI and cognitive functions in multiple sclerosis’ by Pozzilli and colleagues and freely available here. The aim in this study was to clarify the distribution of 99mTc HMPAO (used as a marker of cerebral blood flow) in the brains of people with relapsing-remitting multiple sclerosis with ‘mild physical and cognitive disturbance’. The authors selected 17 people with Multiple Sclerosis from a Multiple Sclerosis outpatient clinic. However the selection criteria aren’t clear – there is no mention of consecutive patients being considered or random assignment otherwise. The exclusion criteria are clearly stated as those with chronic progressive illness and MMSE scores less than 23 or a score greater than 4 on the Kurtzke Expanded Disability Status Scale. There is some information on the sample demographics/scores with an average MMSE of 28.5. I wasn’t able to identify power calculations for estimating sample size.

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