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Quality of life in multiple sclerosis is associated with lesion burden and brain volume measures

Posted Nov 17 2009 10:20pm


Summary: In MS, health-related quality of life (HRQOL) is reduced. However, it is not yet well established that measures related to quality of life are to be taken into account as outcome measures in clinical trials. In this study the authors have shown that there is a significant association between MRI characteristics such as lesion burden and brain volume loss and HRQOL. These findings strengthen the argument for the use of HRQOL outcome measures in clinical trials.

authors: Mowry EM, Beheshtian A, Waubant E, Goodin DS, Cree BA, Qualley P, Lincoln R, George MF, Gomez R, Hauser SL, Okuda DT, Pelletier D

source: Neurology. 2009 May 19;72(20):1760-5

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