Predicting Clinical Progression With the Magnetic Resonance Disease Severity Scale
Posted Jan 14 2009 8:22pm
Archives of Neurology Vol. 65 No. 11, November 2008 Rohit Bakshi, MD; Mohit Neema, MD; Brian C. Healy, PhD; Zsuzsanna Liptak, MD; Rebecca A. Betensky, PhD; Guy J. Buckle, MD; Susan A. Gauthier, DO; James Stankiewicz, MD; Dominik Meier, PhD; Svetlana Egorova, MD; Ashish Arora, MD; Zachary D. Guss, BA; Bonnie Glanz, PhD; Samia J. Khoury, MD; Charles R. G. Guttmann, MD; Howard L. Weiner, MD Arch Neurol. 2008;65(11):1449-1453.
Background Individual magnetic resonance imaging (MRI) disease severity measures, such as atrophy or lesions, show weak relationships to clinical status in patients with multiple sclerosis (MS).
Objective To combine MS-MRI measures of disease severity into a composite score.
Design Retrospective analysis of prospectively collected data.
Setting Community-based and referral subspecialty clinic in an academic hospital.