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Predicting Clinical Progression With the Magnetic Resonance Disease Severity Scale

Posted Jan 14 2009 8:22pm
Archives of Neurology
Vol. 65 No. 11, November 2008

Rohit Bakshi, MD; Mohit Neema, MD; Brian C. Healy, PhD; Zsuzsanna Liptak, MD; Rebecca A. Betensky, PhD; Guy J. Buckle, MD; Susan A. Gauthier, DO; James Stankiewicz, MD; Dominik Meier, PhD; Svetlana Egorova, MD; Ashish Arora, MD; Zachary D. Guss, BA; Bonnie Glanz, PhD; Samia J. Khoury, MD; Charles R. G. Guttmann, MD; Howard L. Weiner, MD
Arch Neurol. 2008;65(11):1449-1453.


Background Individual magnetic resonance imaging (MRI) disease severity measures, such as atrophy or lesions, show weak relationships to clinical status in patients with multiple sclerosis (MS).

Objective To combine MS-MRI measures of disease severity into a composite score.

Design Retrospective analysis of prospectively collected data.

Setting Community-based and referral subspecialty clinic in an academic hospital.

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