Health knowledge made personal
Join this community!
› Share page:
Go
Search posts:

Possible Link Between Multiple Sclerosis Brain Atrophy, Cognitive Function And Low Vitamin D Levels

Posted May 03 2010 12:00am
May 03, 2010

Low vitamin D levels may be associated with more advanced physical disability and cognitive impairment in persons with multiple sclerosis , studies conducted by neurologists at the University at Buffalo have shown.

Their results, reported at the American Academy of Neurology meeting, held earlier this month, indicated that:
  • The majority of MS patients and healthy controls had insufficient vitamin D levels.

  • Clinical evaluation and magnetic resonance imaging (MRI) images show low blood levels of total vitamin D and certain active vitamin D byproducts are associated with increased disability, brain atrophy and brain lesion load in MS patients.

  • A potential association exists between cognitive impairment in MS patients and low vitamin D levels.
The MRI study involved 236 MS patients -- 208 diagnosed with the relapsing-remitting type and 28 with secondary progressive, a more destructive form of MS -- and 22 persons without MS.

All participants provided blood serum samples, which were analyzed for total vitamin D (D2 and D3) levels as well as levels of active vitamin D byproducts. MRI scans performed within three months of blood sampling were available for 163 of the MS patients.

Results showed that only seven percent of persons with secondary-progressive MS showed sufficient vitamin D, compared to 18.3 percent of patients with the less severe relapsing-remitting type.

Higher levels of vitamin D3 and vitamin D3 metabolism byproducts (analyzed as a ratio) also were associated with better scores on disability tests, results showed, and with less brain atrophy and fewer lesions on MRI scans.

*
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

"Providing You with 'MS Views and News', is What We Do"
Remain up-to-date and Informed with Multiple Sclerosis News and Information. If not yet receiving the"Stu's Views and MS Related News", weekly M.S. e-newsletter, then please take 20 seconds to register at: http://www.msviewsandnews.org . - - Thank you -
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Post a comment
Write a comment:

Related Searches