Pediatric optic neuritis: brain MRI abnormalities and risk of multiple sclerosis
Posted Nov 17 2009 10:20pm
The authors of this article aimed to investigate MRI factors involved in a higher risk of development of MS after an episode of optic neuritis in children. The risk of MS significantly increased in children with at least one lesion seen on a brain MRI performed during the episode of optic neuritis. Children with normal scans had a very low risk of developing MS.
source: Neurology. 2009 Mar 10;72(10):881-5 - pubmed -
Bonhomme GR, Waldman AT, Balcer LJ, Daniels AB, Tennekoon GI, Forman S, Galetta SL, Liu GT. Division of Neuro-Ophthalmology, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
BACKGROUND: Optic neuritis is often the initial presentation of multiple sclerosis (MS). As established by the Optic Neuritis Treatment Trial, an abnormal baseline brain MRI is a strong predictor of MS after isolated optic neuritis in adults. However, the rate of conversion to MS after optic neuritis in children based upon brain MRI findings is unknown.