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Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclero

Posted Jan 14 2009 8:23pm
PubMed - 2008 Sep 5
Aharonowiz M, Einstein O, Fainstein N, Lassmann H, Reubinoff B, Ben-Hur T.

The Hadassah Human Embryonic Stem Cells Research Center, The Goldyne Savad Institute of Gene Therapy, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

This study of stem-cell therapy in an animal model of MS showed improvement of the clinical signs, inflammation and brain injury. However these changes were not due to remyelination, instead appearing to be related to a change in the immune response.

BACKGROUND: Multiple sclerosis (MS) is an immune mediated demyelinating disease of the central nervous system (CNS). A potential new therapeutic approach for MS is cell transplantation which may promote remyelination and suppress the inflammatory process.

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