Neuropsychiatry Division, Dept. of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, FG08-2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.
Pseudobulbar affect (PBA) is defined as episodes of involuntary crying, laughing, or both in the absence of a matching subjective mood state. This neuropsychiatric syndrome can be found in a number of neurological disorders including multiple sclerosis (MS). The aim of this study was to identify neuroanatomical correlates of PBA in multiple sclerosis (MS) using a case-control 1.5T MRI study. MS patients with (n = 14) and without (n = 14) PBA were matched on demographic, disease course, and disability variables.
Comorbid psychiatric disorders including depressive and anxiety disorders were absent. Hypo- and hyperintense lesion volumes plus measurements of atrophy were obtained and localized anatomically according to parcellated brain regions.
Neuroanatomy of pseudobulbar affect : a quantitative MRI study in multiple sclerosis.
Ghaffar O, Chamelian L, Feinstein A.
Neuropsychiatry Division, Dept. of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, FG08-2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.
Pseudobulbar affect (PBA) is defined as episodes of involuntary crying, laughing, or both in the absence of a matching subjective mood state. This neuropsychiatric syndrome can be found in a number of neurological disorders including multiple sclerosis (MS). The aim of this study was to identify neuroanatomical correlates of PBA in multiple sclerosis (MS) using a case-control 1.5T MRI study. MS patients with (n = 14) and without (n = 14) PBA were matched on demographic, disease course, and disability variables.
Comorbid psychiatric disorders including depressive and anxiety disorders were absent. Hypo- and hyperintense lesion volumes plus measurements of atrophy were obtained and localized anatomically according to parcellated brain regions.
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