IT’S JUST THE TIP OF THE ICEBERG A New Paradigm For MS
Posted Nov 17 2009 10:20pm
Information provided by Maria Z., in Miami
The diagnosis of “secondary progressive MS” has long been thought to mark a shift in the course of the disease from a primarily inflammatory process to a neurodegenerative one. Although the majority of people with MS are initially diagnosed as “relapsing-remitting,” about half of them, after ten years, will transition to a secondary progressive disease course. This progressive phase is characterized by gradual loss of function and thought by some to herald a shift in MS pathology--from inflammation to some other process that causes neurons to die in the absence of inflammation. The nature of this “neurodegenerative process” has never been well understood. An important study, published in March of 2009, in the journal Brain, has provided some surprising new information on this topic.