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FTY720 therapy, exerts differential effects on T cell subsets

Posted Jan 14 2009 8:22pm
Source: PubMed
2008 Oct 14;71(16):1261-7

Department of Biomedicine and Neurology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.

In this study the authors found changes in the T cells in the blood, a type of cell involved in the immune response, in people who received a new tablet medication called FTY720 which is under investigation in MS.

authors: Mehling M, Brinkmann V, Antel J, Bar-Or A, Goebels N, Vedrine C, Kristofic C, Kuhle J, Lindberg RL, Kappos L

BACKGROUND: The oral immunomodulator FTY720 has shown efficacy in patients with relapsing multiple sclerosis (MS). FTY720 functionally antagonizes sphingosine 1-phosphate receptor-1 (S1P1) on T cells and consequently inhibits S1P/S1P1-dependent lymphocyte egress from secondary lymphoid organs. Little is known about the phenotype and function of T cells remaining in peripheral blood during long-term FTY720 treatment.

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