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Expert Panel Publishes Findings on Benefits of Underutilized Intrathecal Baclofen Therapy for Severe Spasticity in Multiple Scle

Posted Feb 04 2011 12:00am

Consensus Paper Suggests Medtronic ITB Therapy is an Effective Treatment for Control of Severe Spasticity, a Frequent and Disabling Symptom of MS
MINNEAPOLIS – February 3, 2011 – A new scientific article has been published demonstrating the profound impact of spasticity on patients with multiple sclerosis and the benefits and underutilization of intrathecal baclofen (ITB) therapy from Medtronic, Inc. (NYSE: MDT) as a treatment option for these patients. The paper, published this week as an OnlineFirst article in Multiple Sclerosis Journal,recommends physician evaluation of ITB therapy as a treatment option for patients at all clinical stages of MS who are intolerant of or unresponsive to oral spasticity therapies.
“Severe spasticity is a debilitating condition that can have a negative impact on quality of life of patients with MS.  While oral medications work to treat spasticity in some individuals, I see patients every day who can’t tolerate the side effects of large doses of medication necessary to treat the most severe cases,” said Mary Hughes, M.D., one of the article’s authors and chair, Division of Neurology, University Medical Group, Greenville Hospital System University Medical Center in Greenville, S.C. “The strong collection of clinical results on the use of ITB therapy in MS patients points to a clear need for physicians to help MS patients control their spasticity and restore quality of life with options like ITB therapy, which is safe and effective in carefully selected patients.”
The expert panel of authors, including leading MS clinicians from the United States and Europe, combined has more than 100 years of experience in MS management and has treated more than 1,500 MS patients worldwide. The article includes a review of literature on ITB therapy for spasticity in MS and provides expert opinion of the panel regarding patient selection and management of ITB therapy in MS patients. Medtronic sponsored the panel’s meeting and paper development.
According to survey results within the research summary, 84 percent of patients with MS reported at least some symptoms of spasticity, with 30 percent reporting moderate to severe symptoms. Of the 13 percent of MS patients who may be candidates for ITB therapy, only 1 percent of patients stated they were receiving the therapy. However, current data indicate that ITB therapy effectively and significantly reduces severe spasticity in ambulatory and non-ambulatory patients with MS.
The expert panel noted that the main barrier to the use of ITB therapy is that many physicians do not present ITB as a therapeutic option that is safe, effective and well-tolerated. This often occurs due to a lack of physician understanding of quality of life issues caused by spasticity, potential ITB benefits and appropriate patient selection, as well as their focus on disease-modifying therapies rather than symptom control.
“This article is a very powerful analysis of the need for greater consideration of ITB therapy by clinicians who manage MS,” said Tom Tefft, senior vice president and president of the Neuromodulation business at Medtronic. “We are hopeful that this paper will encourage more physicians to offer the therapy to appropriate patients.”


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