Early MRI in optic neuritis: the risk for clinically definite multiple sclerosis
Posted Jan 26 2010 12:00am
Info provided by Karen D in South Florida:
First Published Jan 20, 2010
MRI brain lesions at presentation with optic neuritis (ON) increasethe risk for developing clinically definite (CD) multiple sclerosis(MS). More detailed early MRI findings may improve predictionof conversion.
The objectives of this study were to investigatethe influence of number, location and activity of lesions atpresentation, new lesions at early follow-up and non-lesionMRI measures on conversion from optic neuritis (ON) to CDMS.
142/143ON patients, prospectively recruited into a serial MRI and clinicalfollow-up study, were followed-up at least once. Cox regressionanalysis determined independent early MRI predictors of timeto CDMS from: (i) baseline lesion number, location and activitymeasures, (ii) three-month lesion activity measures and (iii)brain atrophy, magnetization transfer ratio and spectroscopymeasures.
114/142 (80%) had abnormal baseline brain or cord MRI.57 (40%) developed CDMS (median of 16 months from clinicallyisolated syndrome onset). Median follow-up of the non-converterswas 62 months. Multivariate analysis of baseline parametersrevealed gender, periventricular and gadolinium-enhancing lesionsas independent predictors of CDMS. Considering both scans together,gender, baseline periventricular and new T2 lesions at follow-upremained significant (hazard ratios 2.1, 2.4 and 4.9, respectively).No non-conventional measure predicted CDMS.
It was concludedthat new T2 lesions on an early follow-up scan were the strongestindependent predictor of CDMS.
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