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Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis

Posted Nov 17 2009 10:20pm
MSIF news

summary: The aim of this cross-sectional study was to investigate whether the disruption of specific white matter tracts could be involved in cognitive dysfunction in patients with MS. The authors found that cognitive dysfunction was strongly correlated with not only the presence of lesions in certain brain regions, but also with damage in some other areas with no lesions but with a high disorganization, suggesting disruption of the underlying anatomical connections within the brain.

authors: Dineen RA, Vilisaar J, Hlinka J, Bradshaw CM, Morgan PS, Constantinescu CS, Auer DP
source: Brain. 2009 Jan;132(Pt 1):239-49

Department of Academic Radiology, Queen's Medical Centre, University of Nottingham, Nottingham, UK . robert.dineen@nhs.net

Disconnection of cognitively important processing regions by injury to the interconnecting white matter provides a potential mechanism for cognitive dysfunction in multiple sclerosis. The contribution of tract-specific white matter injury to dysfunction in different cognitive domains in patients with multiple sclerosis has not previously been studied.

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