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Cognitive decline in multiple sclerosis: impact of topographic lesion distribution

Posted Aug 18 2009 10:43pm
Cognitive decline in multiple sclerosis: impact of topographic lesion distribution on differential cognitive deficit patterns

Some people with MS can develop some degree of cognitive impairment. Although brain volume loss, which can occur in people with MS, and the lesion load are associated with cognitive dysfunction, the exact mechanisms that determine this cognitive decline are not yet fully understood. In this article the authors have shown that the brain volume loss in deeper regions of the brain seems to play a more important role in determining cognitive impairment in people with MS than the total lesion load.

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