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Bone-marrow transplantation fails to halt intrathecal lymphocyte activation in multiple sclerosis

Posted Jan 14 2009 8:23pm
PubMed - Sept 2008

Mondria T, Lamers CH, te Boekhorst PA, Gratama JW, Hintzen RQ.
Department of Neurology, Erasmus University Medical School, Erasmus MC, 3000 CA Rotterdam, The Netherlands.

BACKGROUND: Given the presumed key role for autoreactive lymphocytes in multiple sclerosis (MS), treatment strategies have been developed to ablate lymphocyte activity. Intrathecal lymphocyte activation can be measured by CSF-soluble(s)CD27.

OBJECTIVE: To determine the effect of maximum whole-body immune ablation on two different markers that detect lymphocyte activation in CSF-oligoclonal IgG bands and levels of CSF-sCD27.

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