So who knows the skinny on Baclofen? It's been doing an incredible job with the cramps and pain in my legs, very happy about that. I took Baclofen years ago, didn't like how it relaxed my legs at the time. It did the same thing this time, but I stuck with it, increased the dose, and have adjusted. What caught me off guard was what it did to my right hand, the same thing it did to my legs. Can't brush my teeth right now with the right hand, use a comb, scissors, cut meat, or even write. I'm hoping I will be able to rehab the hand, get some use out of it again. Tough when the trade of for not being in agony is lose of use, but I'm thinking it's pretty worth it at this point.