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Antihistamines Can Worsen MS-Related Fatigue

Posted Jan 14 2009 8:24pm 1 Comment
Info providedByJulie Stachowiak, Ph.D., About.com
Updated: July 18, 2008

Fatigue Can Be a Side Effect of These Antihistamine Medications


Fatigue and Multiple Sclerosis

Most of us withMultiple Sclerosis (MS) suffer fromfatigue. In fact, an estimated 70% of people with MS say that fatigue is their most disabling symptom. While much of our fatigue comes from the disease process itself orMS-related heat intolerance, there are many secondarycauses of fatiguein MS. One thing that may be contributing to your fatigue could actually be some of the medications that you are taking to slow your MS or deal with specificsymptoms. If you suffer from MS-related fatigue, it is important to investigate all possible causes, including side effects from some of your medications.

Use of Antihistamines By People With Multiple Sclerosis

Histamines are chemicals released by the body’s inflammatory cells during an allergic reaction, which results in classic allergy symptoms such as itching, sneezing, runny nose, congestion and irritated eyes. Antihistamines block the actions of these histamines, thereby reducing the allergic response.

Many of us all have allergies from time to time, and antihistamines can make us much less miserable. You should know, however, that antihistamines can contribute to fatigue, even if they are used as nasal sprays or eye drops. Also, be aware that many of these can be purchased over-the-counter but still have side effects. They are commonly mixed in with other medications to provide multisymptom relief, such as cold and flu medications, and often available as “store brands,” so look carefully at the list of active ingredients. They are also often specifically added to other drugs (Tylenol PM or NiQuil) to help people sleep. Be aware that even some of the “nondrowsy” allergy medications can still affect those of us struggling with MS-related fatigue enough to be noticed.

The bottom line is to use antihistamines wisely – speak with your neurologist if you suspect that your fatigue is worsened by the use of your antihistamines. Maybe he or she can help you find another solution.

But “Fatigue” Isn’t Listed as a Side Effect of My Drug:

Most of the medications listed below have “tiredness” or “drowsiness” as a potential side effect. Some list “dizziness” or “weakness.” Others also have side effects, such as “sweating,” “trembling,” “difficulty breathing,” “lightheadedness,” “flushing,” “confusion,” “nausea/vomiting” or “fainting spells.” For someone that does not have MS, many of these effects could just be a passing annoyance. For those of us, though, who battle MS-related fatigue on a daily basis, any of the discomforts listed above may be enough to tip the balance between a good day and a bad day, fatiguewise.

Note to My Non-U.S. Friends: The list below includes brand names of drugs prescribed in the United States. For people in other countries, please refer to the generic name of the medication, which may be spelled differently depending on the country. Thanks for your understanding.

List of Antihistamines that Can Contribute to Fatigue in People with MS

Azelastine(Astelin): An antihistamine that is available as an eye solution or nasal spray.

Cetirizine(Zyrtec): An antihistamine that is used to treat both seasonal and year-round allergies as well as to treat hives and chronic itchy skin. It is available as chewable tablets, oral syrup or tablets.

Chlorpheniramine(Aller-Chlor, Chlor-Trimeton, and Teldrin as an ingredient in many store brands of allergy medicines): An antihistamine used to treat symptoms of allergies and colds. It is available as oral syrup, effervescent tablets, tablets or capsules.

Diphenhydramine(Benedryl): An antihistimine that reduces allergic reactions and vertigo, available as an injection, oral syrup or elixir, solution, tablets or capsules. It is also found in many types of cold medications or nighttime pain relief medicine (Advil PM, Tylenol PM) to help people sleep.

Loratadine(Claritin): An antihistamine to help relieve allergy symptoms, such as hay fever and itching. It is available as oral syrup or solution or tablets.

Phenylephrine(Neo-Synephrine): Specifically for eye allergies or symptoms, available as eye solution, nose drops, spray, jelly, quick-dissolve strips or tablets.

Doxylamine(Unisom Sleeptabs, NyQuil, many store brands): This is an antihistamine that is primarily used as a sleep aid, either added to other medications or by itself. It is available as tablets, capsules or syrups.


READ MORE by visiting theaboutMS.comwebsite


Comments (1)
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I use Benedryl (diphenhydramine) on occasion to help me sleep. Since it is an antihistamine that crosses the blood brain barrier thereby inducing drowsiness as well as reducing swelling or inflamation caused by histamines is it possible that it may be useful in the treatment of MS? All I've seen is negative info related to fatigue. Ironically I find the good night's sleep I get from using the antihistamine leaves me rested and less fatigued.
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