Although several dietary supplements are sometimes recommended for Migraine prevention, those recommendations are mostly based on anecdotal evidence rather than clinical trial results. With no medications on the market specifically developed for Migraine prevention, the search for effective preventives is perpetual. Along with the various prescription medications, "natural" products are of significant interest to Migraineurs.
An open label trial of coenzyme Q10 (CoQ10) as a Migraine preventive was very promising.1 The results were published in Cephalalgia. The introduction to the article states:
"At present there are very few efficacious migraine preventives and fewer without significant side-effects. In medicine there has been a trend towards the development of natural therapies that can be safely taken by all who suffer with a disease regardless of age and past medical history. Migraine in particular is a disorder of young people and this patient population is very resistant to taking any form of medication, especially when it needs to be used on a daily basis. Migraine can be a disabling disorder and migraine preventives have been shown to not only reduce headache frequency, intensity and duration but also improve quality of life. Coenzyme Q10 is a naturally occurring substance and essential element of the mitochondrial electron transport chain. It has been the most extensively studied agent for the treatment of mitochondrial disorders and has been shown to have almost no identifiable side-effects in humans. There has been a recent interest in the role that mitochondria may play in migraine pathogenesis ... The objective of this investigation is to assess the efficacy of coenzyme Q10 as a preventive treatment for migraine."