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Omega-3 Is Not the Bullet

Posted Oct 27 2009 11:01pm

fish
A new study of heart patients suffering from depression is in itself depressing — at least if you were excited about the potential of omega-3 fatty acids to life your spirits. From the New York Times:

The patients were randomly assigned to a combination of sertraline, an anti-depressant, and either omega-3s or a corn oil placebo. After 10 weeks, there was “absolutely no difference” in depression remission rates between the 59 patients taking omega-3s and the 56 patients taking the placebo, said Robert M. Carney, lead author of the study, which appeared in the Oct. 21 issue of the Journal of the American Medical Association.

“It was very disappointing,” he said.

The trial was launched because patients with heart disease are at greater risk of dying if they are depressed, Dr. Carney said. Depressed patients are known to have low levels of omega-3s, which are a risk factor for heart disease, as well.

Now, with any study, there are multitudinous caveats. It’s a small sample. They had lower levels of omega-3s to begin with. Perhaps there were other factors (i.e., physical illness) that superseded the treatment of depression, yadda yadda.

And there has been other research to suggest omega-3s are useful for depression. USA Today broke down a different study in 2007:

The omega-3 fatty acid in some fish may be a “brain food” that helps ward off depression because it increases gray matter in three areas that tend to be smaller in people who have serious depression, a study suggests today.
The increase could help explain why past studies have found that the omega-3 acid DHA reduces symptoms of depression. The richest sources of DHA are fatty fish and fish-oil capsules.

Researchers gave magnetic resonance imaging tests to 55 adults. Participants also reported everything they ate for 24 hours on two randomly selected days, says study leader Sarah Conklin, a neuroscientist at University of Pittsburgh Medical School. She’ll report her findings at the American Psychosomatic Society meeting in Budapest.

The more DHA a person consumed, the more gray matter there was in three areas of the brain linked to mood: the amygdala, the hippocampus and the cingulate, Conklin says. Seriously depressed people tend to have less gray matter in these areas, she says.

For every yes in research, there’s a no. It’s really frustrating for people looking for answers. That’s why it’s best to just go with your gut: Try what feels right and if it works for you, great. If it doesn’t work for you, move on to something else. But remember: There is no magic bullet — oily or otherwise.


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