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Is nicotine a stimulant or a depressant?

Posted Aug 04 2012 2:49pm

Is Tobacco an upper or a downer?

Half the articles I read tell me that Nicotine is a depressant. The other half, just as authoritatively, says it is a stimulant. It can’t be both, can it?

Smokers will tell you that when they get up in the morning they need a smoke to wake them up and get them going. Those very same smokers will tell you that at bed time then need one last cigarette to calm them down and put them to sleep. How is this working?

Nicotine is one of a very small group of chemicals, probably the only one that is in common use, which works as both a stimulant and a depressant. Chemicals like this are called Biphasic.

Pure Nicotine is very, very poisonous. As an insecticide in its pure form it will kill insects like crazy. But as a pure chemical if it is sprayed on a field and gets on workers, those laborers will end up in the hospital and may die. So why doesn’t it kill smokers, quick like. If it killed you the first time you used it, there wouldn’t be many long term smokers would there?

The nicotine from three pacts of cigarettes, if consumed in pure form, would kill the average adult. A child could die from much less. Most of the nicotine in a cigarette is broken down by the burning and is taken in slowly, a small amount at a time. The result is a chronic low level of the poisonous chemicals in the blood stream rather than a single large fatal dose. A small child or pet eating a few cigarettes could reach a toxic, fatal level.

Most cases of nicotine poisoning and death are the result of being exposed to highly concentrated nicotine used as an insecticide. While nicotine was commonly used as an insecticide in the past, it has been replaced by newer more modern insecticides.

The one area in which nicotine is still permitted is in “organic” crops since nicotine is derived from a plant. Some countries have banned the use of nicotine as an insecticide and it appears likely that even the use for organic food will soon be eliminated.

In the early stages the nicotine stimulates many responses in the body. The smoker by taking in that first puff in the morning believes they are energized.  

As the day progresses the levels of nicotine in the blood stream fluctuates. After each smoke the level rises. The body, principally the liver, attempts to remove the toxin and the level is reduced. This up-down action creates the craving the smoker experiences.

The administration of any drug in many small doses, particularly by smoking, increases the addiction potential.

Late in the day the smoker will have achieved a relatively high level of nicotine in the blood stream. At high doses the nicotine begins to depress systems in the body. Just before bedtime the habitual smoker will smoke more in a shorter period of time in an effort to relax for sleep. The level of nicotine will slowly fall during the night as the liver detoxifies the drug.

Smokers instinctively respond to this low dose high dose affects. A smoker who is trying to feel stimulated will take many short puffs. The smoker trying to sedate themselves will take fewer long puffs and raise the level in the blood stream more rapidly.

It seems likely that many poisonous chemicals would affect the body in the same biphasic way. At low doses the poison stimulates the body to defend itself and at high doses the body shuts down under the effects of the poison. Nicotine, unlike many other poisons, is different in that it is able to produce these body and mind altering effects which users find so pleasant while producing the diseases and death slowly over time rather than quickly.  

Tobacco keeps its users alive and dependent on it for their mood state changes for as long as she can.

Why does the effects of nicotine on the body matter to readers of a blog on mental health and substance abuse issues?

Because, by one report, the majority of cigarettes consumed in America are smoked by people with a diagnosed mental illness.

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