“Low HDL Cholesterol Is a Risk Factor for Deficit and Decline in Memory in Midlife. The Whitehall II Study,” Singh-Manoux A, Gimeno D, et al, Arterioscler Thromb Vasc Biol, 2008; [Epub ahead of print]. (Address: INSERM u687-IFR69, the Department of Epidemiology and Public Health, University College London, UK; and the Centre de G�rontologie, H�pital Ste P�rine, AP-HP, France).
In a study involving 3,673 male and female middle-aged subjects, subjects with low HDL-cholesterol (< 40 mg/dL) were found to have a greater odds of memory deficit (short-term verbal memory). In a fully adjusted analysis, as compared to subjects with high HDL-cholesterol (>/= 60 mg/dL), the odds ratio of memory deficit was 1.27 in the first wave of the study and 1.53 in the second wave of the study in subjects with low HDL-cholesterol levels. Over the course of a 5-year follow-up period, decreases in HDL-cholesterol were associated with declines in memory (OR=1.61). The authors conclude, “HDL-C levels are potentially modifiable, and our results suggest that low HDL-C is associated with poor memory and decline in memory in middle-aged adults.”
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