Depressive symptoms of ‘Bipolar Disorder’ reduced in a study done in Australia. From Vitasearch - 
| Summary# | 46383 | | Topic: | N-Acetylcysteine May Reduce Depressive Symptoms in Persons with Bipolar Disorder | | Keywords: | BIPOLAR DISORDER, DEPRESSION, DEPRESSIVE, MENTAL HEALTH - N-Acetylcysteine, NAC, Glutathione | | Reference: | “N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder-A Double-Blind Randomized Placebo-Controlled Trial,” Berk M, Copolov DL, et al, Biol Psychiatry, 2008 June 4; [Epub ahead of print]. (Address: The Mental Health Research Institute of Victoria, Victoria, Australia; Department of Clinical and Biomedical Sciences, The University of Melbourne, Geelong, Australia). | | Summary: | In a randomized, double-blind, placebo-controlled, 6-month, multicenter study involving 75 subjects with bipolar disorder (maintenance phase), treatment with N-acetylcysteine (NAC - a precursor of glutathione; glutathione depletion is known to exist in both depression and bipolar disorder) at a dose of 1 g/twice daily, as an adjunct to standard medication, was found to reduce depressive symptoms. A significant decrease in the Montgomery Asberg Depression Rating Scale (MADRS) was found (-8.05) 5 months after starting supplementation with NAC. Improvements in the Global Assessment of Functioning Scale and Social and Occupational Functioning Assessment Scale were found 2 months after beginning NAC supplementation. Considering the fact that treatment-resistant subthreshold depression is a major problem in bipolar disorder, the results of this study, suggesting that NAC may be an effective adjunctive treatment in patients with bipolar disorder, offer hope |
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Depressive symptoms of ‘Bipolar Disorder’ reduced in a study done in Australia.
From Vitasearch -
For more information on nutrition and integrative medicine, visit [ Vitasearch ].
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Filed under Bipolar Disorder, Depression, Nutrition, Research
Tags: N-Acetyl Cysteine, NAC