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New Study Helps Women make Informed Decision about BHRT

Posted Oct 10 2012 3:43pm


If you have been pondering whether or not to pursue hormone therapy for menopause relief, here’s a few new facts that might help make your decision easier.


bioidentical hormone therapy The KEEPS study

The Kronos Early Estrogen Prevention Study (KEEPS) began four years ago and was designed to test the safety and efficacy of micronized (bioidentical) progesterone combined with either oral (traditional) estrogen (o-CEE) or transdermal (bioidentical) estrogen (t-E2) to treat symptoms of menopause in healthy women aged 42 to 58.

Unlike the Women’s Health Initiative (WHI) that erupted fear of hormone therapy, the KEEPS study used micronized (bioidentical) progesterone because it more accurately and effectively mimics a woman’s natural cycle. In the WHI, traditional (synthetic) progesterone was used along with traditional (synthetic) estrogen, which as many know resulted in adverse health effects in many of the subjects.

  • No increased risk of breast or ovarian cancer
  • Reduced symptoms of menopause including mood swings, low libido, hot flashes, night sweats
  • Reduction in markers of cardiovascular disease (non-significant, due to small study size)
  • Women on the  o-CEE experienced fewer mood swings than women on a placebo or t-E2
  • Women on the t-E2 experienced vast improvements in sexual function and desire
  • Women on t-E2 experienced improved insulin sensitivity (lowered blood sugar levels)
  • The o-CEE appeared to raise triglyceride levels slightly, while reducing LDL (bad cholesterol) levels and raising HDL levels (good cholesterol)
  • Both, t-E2 and o-CEE had no impact on blood pressure levels

And, a new Danish study found evidence that hormone therapy reduces risk of cardiovascular death. Read more here:


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