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Estrogens and estrogen antagonists (Antiestrogens)

Posted Sep 08 2012 1:35am

Estrogens and estrogen antagonists (Antiestrogens)

Article by Mat Hall

Gynecomastia, that is breast enlargement, has become the hallmark of the power and curse in the sports sphere. Larger males grow breasts, but the point here is not transsexualism. Everything is much easier – steroids are to be blamed. The evil demon, inflicting femininity in men is a female sex hormone – estrogen. Actually estrogen is a group of female sex hormones synthesized in the body and the ovaries regulate specific sexual functions. It would be truer to say of estrogens since they have two (both women and men). The main and most powerful of them – 17-beta estradiol, which is mostly obtained from progesterone by the ovaries. Smaller amounts can be obtained from testosterone by the enzyme reactions. In the male the whole body of estradiol produced by enzymes bearing the name of the aromatase. Even the one that stands out in the testes, testosterone is derived from, evolved Leydig cells by enzymatic conversion in the Sertoli cells. Second, a weaker estrogen is estrone. It is also synthesized by the ovaries of the emitted adrenal androstenedione.

Estrogens are naturally present in the male body, as do a number of important functions. Many areas of the brain contain estrogen receptors. In 1981, it has been hypothesized that estrogens regulate the level of luteinizing hormone, and therefore of testosterone in animals and human male. Around the same time it was suggested the possibility of (safe, though too radical), increase testosterone levels by inhibiting the synthesis of estrogen, German scientists published a similar conjecture. In addition, estrogens are involved in the regulation of libido, that is, sexual desire, maintain an acceptable level of HDL (“good” cholesterol) and regulate the development of the fetus in the placenta. In addition to the foregoing, testosterone and estrogen work synergistically – without their mutual muscles will not grow. Consequently, the maintenance of balance in the male body is as follows: athletes are going to lower estrogen levels just enough to prevent gynecomastia, and the balance they are still regulates the libido and the level of “good” cholesterol. Those who take anabolic steroids, there are two possibilities. Either they will avoid steroids convert to estrogen or antiestrogenic use tools.

Even “clean” athlete would like to raise testosterone levels. Anti-estrogens gove such an opportunity. Because these drugs are widely used (as a primary means) in the treatment of estrogen-dependent breast cancer, the bodybuilders have a choice. There are four major categories of anti-estrogens: non-steroidal antagonists, steroid anti-aromatized substances, synthetic anti-aromatized drugs and natural substances of aromatase blockers.

Clomid (clomiphene) had originally to act as an antagonist of estrogen. In fact, it has a dual action (as an agonist / antagonist), i.e., blocking effects of estrogen receptors and mimics the action of luteinizing hormone by increasing the synthesis of estrogen in the ovaries. When it was found that prolonged use of Clomid causes cysts (vesicular tumors in the ovary, it began to prescribe short courses (less than 5 days) to increase fertility. However, for men Clomid has a very useful dual action: it blocks the effects of estrogen and raises testosterone levels. It looks like Clomid is safe for men with chronic administration, but no reports of its effect on libido. Clomid blocks the action of estrogen and also increases testosterone levels. Men usually use two tablets per day (see: Dan Duchaine. Estrogen blockers. – MuscleMedia 2000, February 1997, p. 138).

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