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Aristolochic Acid Nephropathy by Matt S. Posted in: Blog Posts in Kidney Failure Organ donation from HIV positive patients has been prohibited in the USA since 1988. Pre-transplant screening for HIV is mandatory using nuclear amplification test (N ... Read on »
Ultrasound and Nephrologists by Matt S. Posted in: Blog Posts in Kidney Failure At ASN Kidney Week there was some interest in abatacept as a targeted therapy for glomerular diseases. T-cell activation requires 2 signals; (i) binding of the T-cel ... Read on »
Management of CMV after transplantation by Matt S. Posted in: Blog Posts in Kidney Failure Pre-transplant: All the donors and recipients of kidney transplants (both living and deceased) should be tested for status of CMV by CMV IgG in the blood. If ... Read on »
Tolvaptan and the FDA - A patient's perspective by Matt S. Posted in: Blog Posts in Kidney Failure Over at the Atlantic this week, an article was published written by one of the people who took part in the early trials of tolvaptan for APKD. The article shows just how ... Read on »
Induction Therapy in Kidney Transplantation - Summary by Matt S. Posted in: Blog Posts in Kidney Failure Most kidney transplant centers in the United States utilize induction agents as part of their immunosupression protocols. The reasoning behind is that induction therapy has ... Read on »
Diuretics vs. Ultrafiltration: Isn’t the debate settled yet? by Matt S. Posted in: Blog Posts in Kidney Failure We have all been called in to see patients who have developed AKI after receiving mechanical ultrafiltration (UF) for acute decompensated heart failure (ADHF). In almos ... Read on »
Diabetes: To Biopsy or not to Biopsy - Part 2 by Matt S. Posted in: Blog Posts in Kidney Failure In my experience the appetite to biopsy patients with clinical renal disease varies widely between clinician, institution and country. This is most apparent when it come ... Read on »
An Update on Alloantibody and Post-Transplant Failure by Matt S. Posted in: Blog Posts in Kidney Failure There have been a number of studies reported in the past month which broaden our understanding of the complexity of alloantibodies post kidney transplant. It is well rec ... Read on »
IgG4 related kidney disease: A new disease or an old disease raising its head? by Matt S. Posted in: Blog Posts in Kidney Failure I recently managed an elderly African American man who was admitted from the clinic for a renal biopsy. He was referred for proteinuria that had not been quan ... Read on »
Type B Lactic Acidosis by Matt S. Posted in: Blog Posts in Kidney Failure Nice case report in AJKD recently raised the issue of Type B Lactic Acidosis. Lactic acidosis occurs when there is excessive anaerobic glycolysis or decreased removal of ... Read on »
The end of the road for urinary eosinophils? by Matt S. Posted in: Blog Posts in Kidney Failure Nate wrote a couple of posts in the past about the use (and misuse) of urinary eosinophils for the diagnosis of acute interstitial nephritis (AIN). Since the original re ... Read on »
Statins and Chronic Kidney Disease by Matt S. Posted in: Blog Posts in Kidney Failure There is an excellent review of the use of statins is CKD in KI from last month. The authors point out that the association between LDL cholesterol and CVD is not as str ... Read on »
CKD after AKI in the ICU by Matt S. Posted in: Blog Posts in Kidney Failure I give a regular talk to the residents in the ICU on CRRT and one of the things that I focus on is prognosis. We all know that the outcomes of patients requiring CRRT in ... Read on »
Could this be Refeeding Syndrome? by Matt S. Posted in: Blog Posts in Kidney Failure A young patient who was engaging in heavy weightlifting presented to the ED with proximal muscle weakness. The night before he had one hour of acute onset bilat ... Read on »
Kidney Biopsy Case: AKI by Matt S. Posted in: Blog Posts in Kidney Failure A 54 year old man was referred to the Nephrology service due to AKI after presenting with lethargy and severe thirst. He had a long history of pulmonary and hepatic sarcoid ... Read on »
Diabetes and CKD: Pitfalls - Monitoring response to therapy by Matt S. Posted in: Blog Posts in Kidney Failure The glomerular basement membrane is a thin layer of extracellular membrane proteins that is an important part of the filtration barrier, particularly glomerular permsele ... Read on »
Thromboembolic Prophylaxis in Patients with AFib and CKD: Caught between the Devil and the Deep... by Matt S. Posted in: Blog Posts in Kidney Failure I often get curb-sided by cardiologists and internists for my opinion on using warfarin or other anticoagulants for thromboembolic risk prophylaxis in CKD +/- ... Read on »
Diabetes and CKD - Pitfalls: Cystatin C by Matt S. Posted in: Blog Posts in Kidney Failure Cystatin C has been proposed as an alternative marker of kidney function and studies have shown that CyC is a better predictor of mortality that serum creatinine. Althou ... Read on »
Diabetes and CKD - Pitfalls: Estimating GFR by Matt S. Posted in: Blog Posts in Kidney Failure The routine use of estimating equations for GFR has revolutionized the way that we view renal disease over the last 15 years and although some argue that this has lead t ... Read on »
Don't Eat the Leaves by Matt S. Posted in: Blog Posts in Kidney Failure Hyperoxaluria is an important risk factor for kidney stones, approximately 80% of which are primarily composed of calcium oxalate. Hyperoxaluria is typically diagn ... Read on »