Mark Pool, MD's Posts

ETS2 mediates tumor suppressor function and MET inhibition in lung adenocarcinoma by Mark Pool, MD Posted in: Blog Posts in Cancer There was a very intriguing paper published online by Clinical Cancer Research on May 9 last week that should be of interest for those involved in lung cancer research. The ... Read on »

NKX2-1/TTF-1 drives pulmonary-specific differentiation in lung adenocarcinoma by Mark Pool, MD Posted in: Blog Posts in Cancer Snyder et al. recently published an intriguing report in Molecular Cell (21 March 2013) (featured free article) in which they convincingly demonstrate how tumors in which Nk ... Read on »

CAP releases guidelines for validating whole slide imaging by Mark Pool, MD Posted in: Blog Posts in Cancer The College of American Pathologists has released guidelines for validating whole slide imaging. While stating the lack of FDA approval for using WSI for primary diagnosis, ... Read on »

BRAF mutations in colorectal cancer: mini-review by Mark Pool, MD Posted in: Blog Posts in Cancer There has been a recent flurry of papers and reports from ASCO-GI 2013 pushing more molecular testing in colorectal cancer (CRC) and its clinical significance with regard to ... Read on »

Atomic force microscopy! EMT and idiopathic pulmonary fibrosis by Mark Pool, MD Posted in: Blog Posts in Cancer Here is a very intesting article I recently found with some very cool technology: Abstract: Epithelial-mesenchymal transition (EMT) is closely implicated in the pathogenesis ... Read on »

Imaging tumors in the future by Mark Pool, MD Posted in: Blog Posts in Cancer Baohong Yuan and Joshua Rychak have written an interesting review in the February 2013 American Journal of Pathology that outlines emerging techniques based on ultrasound to ... Read on »

Pathologists to Blame for Hindering Acquisition of Cancer Tissue for Genomic Testing? by Mark Pool, MD Posted in: Blog Posts in Cancer Medscape recently posted an article that discusses the need for standards for acquiring, preserving and storing cancer tissue, citing a recent Viewpoint article in JAMA by D ... Read on »

New Device to Check Margins in Breast Cancer Surgery by Mark Pool, MD Posted in: Blog Posts in Cancer Just a follow-up to yesterday's post regarding surgical margins in breast cancer. Will this device obviate inking the specimen or the debate about how much margin is "enough ... Read on »

Controversy: Surgical Margins in Breast Cancer by Mark Pool, MD Posted in: Blog Posts in Cancer What is a clear margin in breast-conserving cancer surgery? ASCO Connection (link) hosts a point-counterpoint discussion by two contributors regarding surgical margins in br ... Read on »

Video: Dr. Jack West discusses changing views on molecular testing in NSCLC by Mark Pool, MD Posted in: Blog Posts in Cancer The Lungevity blog features a video of Dr. Jack West from Swedish Cancer Institute in Seattle discussing his evolving views regarding molecular testing for actionable driver ... Read on »

Epithelial-Mesenchymal Transition and Lung Cancer: Mechanism for Resistance to EGFR-TKIs? by Mark Pool, MD Posted in: Blog Posts in Cancer Despite all of the encouraging clinical results with molecularly targeted therapies against non-small cell lung cancer, there are still important and significant questions t ... Read on »

General Surgical Pathologist is Dead by Mark Pool, MD Posted in: Blog Posts in Cancer Excellent post from Digital Pathology Blog on the demise of the general surgical pathologist! It's amazing (and worrisome) that this happened so quickly in our field. What h ... Read on »

CAP Public Comment Period for New Biomarker Reporting Checklists by Mark Pool, MD Posted in: Blog Posts in Cancer Take a look at the new cancer biomarker reporting checklists proposed by the College of American Pathologists for breast, colon and lung cancers. You don't have to be a CAP ... Read on »

Multilocular Cystic Renal Cell Carcinoma by Mark Pool, MD Posted in: Blog Posts in Cancer Multilocular cystic renal cell carcinoma is an uncommon but diagnostically challenging variant of renal cell carcinoma that fortunately has an excellent prognosis. Histologi ... Read on »

Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of... by Mark Pool, MD Posted in: Blog Posts in Cancer Thought this was an intriguing abstract. Signaling crosstalk between EGFR and integrins was a hot topic at AACC meeting earlier this year. From Evernote: Impact of the Integ ... Read on »

Lack of NKX2-1 (TTF-1) expression in lung adenocarcinoma and EGFR mutations by Mark Pool, MD Posted in: Blog Posts in Cancer My last post discussed one of the two papers I thought were notably in the October 2012 Journal of Thoracic Oncology. Here's my take on the other paper by Vincentin et al (J ... Read on »

Loss of PTEN as a poor prognostic marker for lung adenocarcinoma by Mark Pool, MD Posted in: Blog Posts in Cancer The October 2012 Journal of Thoracic Oncology presents two papers of interest to pathologists. The first study is a paper by Yanagawa et al. that correlates PTEN expression ... Read on »

All the RAGE in Asthma by Mark Pool, MD Posted in: Blog Posts in Cancer My lab's CAP inspection is finally over!!! Now I can get back to more regular blogging (without guilt). This month's American Journal of Pathology features an intriguing art ... Read on »

Hypersensitivity Pneumonitis: recent updates by Mark Pool, MD Posted in: Blog Posts in Cancer There have been two recent papers reviewing hypersensitivity pneumonitis (HP) that I had to summarize for myself and am sharing with you. While idiopathic pulmonary fibrosis ... Read on »

Apps & Smartphones in Medical Education by Mark Pool, MD Posted in: Blog Posts in Cancer Medical students across the country are coming into a day and age where technology rules, and in a society where iPads and Android phones are voted king, it is no small wond ... Read on »

Mark Pool, MD

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