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WHOLE GENOME SEQUENCES OF THIRTEEN ISOLATES OF BORRELIA BURGDORFERI

Posted Oct 08 2010 2:30pm
UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY.

Press Release here
Date: 10-08-10
Name: Rob Forman
Phone: 973 972 7276
Email: formanra@umdnj.edu

Researchers Determine the Genetic Blueprint of the Lyme Disease Microbe

Researchers Dr. Steven E. Schutzer of UMDNJ-New Jersey Medical School and Dr. Claire M. Fraser-Liggett of the Institute for Genome Sciences, University of Maryland, and their collaborators have made a major achievement toward better understanding Lyme disease, by determining the complete genetic structures of 13 strains of the bacteria that cause the disease.

These new discoveries may accelerate research efforts to diagnose, prevent and treat the disease, which can affect the nervous system, heart, skin and joints. The occurrence of the disease has grown dramatically over the past ten years in the United States and Europe. The research, which was funded by the National Institutes of Health, has been published online ahead of print in the Journal of Bacteriology.


Journal of Bacteriology

Abstract
Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease. Because a single genome sequence is not sufficient to understand the relationship between genotypic and geographic variation and disease phenotype, we determined the whole genome sequences of 13 additional B. burgdorferi isolates that span the range of natural variation. These sequences should allow improved
understanding of pathogenesis and provide a foundation for novel detection, diagnosis, and prevention strategies.
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