KGO-TV Story Highlights LFA-Supported Lupus Investigator
Posted Aug 23 2008 10:50pm
An LFA-supported lupus investigator from Stanford University was featured in a story broadcast on San Francisco’s ABC affiliate KGO-TV. Paul Utz, M.D., Associate Professor of Medicine, and his team have begun studying genetic markers, taken from blood samples, to learn more about the physiology of specific lupus patients.
The story also features LPGA pro golfer and Stanford University women’s assistant golf team coach Salimah Mussani, who has lupus.
The story highlights the promising research underway to understand more about lupus and develop new, safe and effective treatments for the unpredictable and potentially fatal autoimmune disease. It has been more than 40 years since a new drug was approved by the U.S. Food and Drug Administration (FDA) specifically for lupus.
About Dr. Utz’s LFA Research Grant -- "Proteomic Studies in Systemic Lupus Erythematosus"
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease that can progressively damage multiple organs. The pathophysiology of SLE involves antibody formation against self-molecules, including those directed against RNA and DNA. By employing several mouse models of SLE, this proposal will test the hypothesis that the initiation and progression of autoantibody production and end organ disease in SLE requires interferon signaling through three different intracellular proteins called IFNAR-2, STAT-1, and IRF-9. The results can be rapidly translated to the clinic by identifying new targets for drug development, and by discovering novel biomarkers for SLE.