Health knowledge made personal
Join this community!
› Share page:
Go
Search posts:

Type B Lactic Acidosis

Posted Oct 08 2013 12:00am
Nice case report in AJKD recently raised the issue of Type B Lactic Acidosis. Lactic acidosis occurs when there is excessive anaerobic glycolysis or decreased removal of lactate from the circulation. Classically, Type A lactic acidosis is related to tissue hypoperfusion resulting in an increase in anaerobic glycolysis. Type B lactic acidosis occurs despite the presence of sufficient oxygen for aerobic glycolysis. There are a number of important causes
Drugs/ToxinsGlucose-6-phosphatasePyruvate carboxylatePyruvate DehydrogenaseOxidative Phosphorylation DefectsKidney FailureLiver FailureThiamine DeficiencyMalignancy
Metformin Linezolid Propofol Nucleoside Reverse Transcriptase Inhibitors Salicylates Isoniazid Alcohol Cyanide
Enzyme Deficiencies
Other Disorders

The case report in AJKD was a patient with myeloma who developed a severe lactic acidosis. The preference of tumor cells for anaerobic glycolysis has been known since the 1920s and is called the Warburg Effect. It is thought to be due to a combination of increased IGF and TGF-alpha production by tumor cells and thiamine deficiency which is common in patients with malignancies. The discussion in the case report gives a nice summary of the literature.

Post a comment
Write a comment:

Related Searches