Differential Diagnosis of Fibrillary Glomerulopathies
Posted Jan 19 2009 12:00am
The finding of fibrils on electron microscopy of a renal biopsy specimen may be an extremely important clue in establishing the diagnosis. In fact, for many of the conditions listed below, the diagnosis may be based PURELY on a detailed ultrastructural characterization of the fibril, as in fibrillary or immunotactoid glomerulopathy.
The first step in the differential diagnosis of fibrillary glomerulopathies is to divide the condition into an IMMUNOGLOBULIN-MEDIATED versus a NON-IMMUNOGLOBULIN MEDIATED process, which is typically done by immunofluorescent staining against different heavy and light chain classes.